Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

Barbara Anne Jennings, Chun Shing Kwok, Gavin Willis, Victoria Matthews, Pawel Wawruch, Yoon Kong Loke

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Many primary studies have considered the association of polymorphisms of folate metabolism and response to 5-fluorouracil (5-FU) and capecitabine in patients with colorectal cancer. The conclusions from these studies have been conflicting and few have considered large cohorts of patients. Therefore, we have completed a systematic review and meta-analyses to summarize some of the findings to date. We conducted searches for any studies that had addressed the prognostic value of genotype analysis of thymidylate synthetase (TYMS), Methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR).
Original languageEnglish
Pages (from-to)290-304
Number of pages15
JournalPharmacogenetics and Genomics
Issue number4
Publication statusPublished - Apr 2012


  • Colorectal Neoplasms
  • Databases, Genetic
  • Deoxycytidine
  • Fluorouracil
  • Folic Acid
  • Gene Expression Regulation, Neoplastic
  • Genetic Association Studies
  • Genetic Variation
  • Genotype
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase

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