Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

Barbara Anne Jennings; Chun Shing Kwok; Gavin Willis; Victoria Matthews; Pawel Wawruch; Yoon Kong Loke

doi:10.1097/FPC.0b013e328351875d

Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

Barbara Anne Jennings, Chun Shing Kwok, Gavin Willis, Victoria Matthews, Pawel Wawruch, Yoon Kong Loke

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Many primary studies have considered the association of polymorphisms of folate metabolism and response to 5-fluorouracil (5-FU) and capecitabine in patients with colorectal cancer. The conclusions from these studies have been conflicting and few have considered large cohorts of patients. Therefore, we have completed a systematic review and meta-analyses to summarize some of the findings to date. We conducted searches for any studies that had addressed the prognostic value of genotype analysis of thymidylate synthetase (TYMS), Methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR).

Original language	English
Pages (from-to)	290-304
Number of pages	15
Journal	Pharmacogenetics and Genomics
Volume	22
Issue number	4
DOIs	https://doi.org/10.1097/FPC.0b013e328351875d
Publication status	Published - Apr 2012

Keywords

Colorectal Neoplasms
Databases, Genetic
Deoxycytidine
Fluorouracil
Folic Acid
Gene Expression Regulation, Neoplastic
Genetic Association Studies
Genetic Variation
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Tetrahydrofolate Dehydrogenase
Thymidylate Synthase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/FPC.0b013e328351875d

Cite this

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abstract = "Many primary studies have considered the association of polymorphisms of folate metabolism and response to 5-fluorouracil (5-FU) and capecitabine in patients with colorectal cancer. The conclusions from these studies have been conflicting and few have considered large cohorts of patients. Therefore, we have completed a systematic review and meta-analyses to summarize some of the findings to date. We conducted searches for any studies that had addressed the prognostic value of genotype analysis of thymidylate synthetase (TYMS), Methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR).",

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AU - Wawruch, Pawel

AU - Loke, Yoon Kong

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