Fusion of splicing factor genes PSF and NonO (p54(nrb)) to the TFE3 gene in papillary renal cell carcinoma

Jeremy Clark, Yong Jie Lu, Sanjiv K. Sidhar, Chris Parker, Sandra Gill, Damian Smedley, Rifat Hamoudi, W. Marston Linehan, Janet Shipley, Colin S. Cooper

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262 Citations (Scopus)

Abstract

We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcription factor gene at Xp11.2. In addition we define an X chromosome inversion inv(X)(p11.2;q12) that results in the fusion of the NonO (p54(nrb)) gene to TFE3. NonO (p54(nrb)), the human homologue of the Drosophila gene NonA(diss) which controls the male courtship song, is closely related to PSF and also believed to be involved in RNA splicing. In each case the rearrangement results in the fusion of almost the entire splicing factor protein to the TFE3 DIVA-binding domain. These observations suggest the possibility of intriguing links between the processes of RNA splicing, DNA transcription and oncogenesis.

Original languageEnglish
Pages (from-to)2233-2239
Number of pages7
JournalOncogene
Volume15
Issue number18
DOIs
Publication statusPublished - 30 Oct 1997

Keywords

  • Chromosome translocations
  • NonO (p54(nrb)) splicing factor
  • PSF splicing factor
  • Renal cell carcinoma
  • TFE3 transcription factor

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