Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma

Jeremy Clark, Harry Benjamin, Sandra Gill, Sanjiu Sidhar, Graham Goodwin, Jayne Crew, Barry A. Gusterson, Janet Shipley, Colin S. Cooper

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166 Citations (SciVal)

Abstract

The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma, In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-31, in a skeletal myxoid chondrosarcoma. CHN appears to be the human homologue of the rat gene NOR1, which was recently identified as a sequence overexpressed in rat brain cells undergoing apoptosis, Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein in which the C-terminal RNA-binding domain of EWS is replaced by the entire CHN protein, comprising a long N-terminal domain, a central DNA binding domain and a C-terminal ligand-binding/dimerisation domain.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalOncogene
Volume12
Issue number2
Publication statusPublished - 1996

Keywords

  • CHN oncogene
  • Chondrosarcoma
  • Steroid/thyroid receptor

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