Gastrin increases murine intestinal crypt regeneration following injury

Penelope D Ottewell, Carrie A Duckworth, Andrea Varro, Rod Dimaline, Timothy C Wang, Alastair J M Watson, Graham J Dockray, D Mark Pritchard

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed. We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli.
Original languageEnglish
Pages (from-to)1169-1180
Number of pages12
JournalGastroenterology
Volume130
Issue number4
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Animals
  • Benzodiazepinones
  • Cell Line
  • Cell Proliferation
  • Colitis
  • Dextran Sulfate
  • Enteritis
  • Enzyme Inhibitors
  • Fluorouracil
  • Gamma Rays
  • Gastrins
  • Growth Substances
  • Intestinal Mucosa
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Omeprazole
  • Phenylurea Compounds
  • Proton Pump Inhibitors
  • Receptor, Cholecystokinin B
  • Regeneration
  • Wounds and Injuries

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