Gastrin increases murine intestinal crypt regeneration following injury

Penelope D Ottewell; Carrie A Duckworth; Andrea Varro; Rod Dimaline; Timothy C Wang; Alastair J M Watson; Graham J Dockray; D Mark Pritchard

doi:10.1053/j.gastro.2005.12.033

Gastrin increases murine intestinal crypt regeneration following injury

Penelope D Ottewell, Carrie A Duckworth, Andrea Varro, Rod Dimaline, Timothy C Wang, Alastair J M Watson, Graham J Dockray, D Mark Pritchard

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed. We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli.

Original language	English
Pages (from-to)	1169-1180
Number of pages	12
Journal	Gastroenterology
Volume	130
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2005.12.033
Publication status	Published - Apr 2006

Keywords

Animals
Benzodiazepinones
Cell Line
Cell Proliferation
Colitis
Dextran Sulfate
Enteritis
Enzyme Inhibitors
Fluorouracil
Gamma Rays
Gastrins
Growth Substances
Intestinal Mucosa
Mice
Mice, Inbred Strains
Mice, Transgenic
Omeprazole
Phenylurea Compounds
Proton Pump Inhibitors
Receptor, Cholecystokinin B
Regeneration
Wounds and Injuries

Access to Document

10.1053/j.gastro.2005.12.033

Cite this

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title = "Gastrin increases murine intestinal crypt regeneration following injury",

abstract = "A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed. We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli.",

keywords = "Animals, Benzodiazepinones, Cell Line, Cell Proliferation, Colitis, Dextran Sulfate, Enteritis, Enzyme Inhibitors, Fluorouracil, Gamma Rays, Gastrins, Growth Substances, Intestinal Mucosa, Mice, Mice, Inbred Strains, Mice, Transgenic, Omeprazole, Phenylurea Compounds, Proton Pump Inhibitors, Receptor, Cholecystokinin B, Regeneration, Wounds and Injuries",

author = "Ottewell, {Penelope D} and Duckworth, {Carrie A} and Andrea Varro and Rod Dimaline and Wang, {Timothy C} and Watson, {Alastair J M} and Dockray, {Graham J} and Pritchard, {D Mark}",

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doi = "10.1053/j.gastro.2005.12.033",

language = "English",

volume = "130",

pages = "1169--1180",

journal = "Gastroenterology",

issn = "0016-5085",

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T1 - Gastrin increases murine intestinal crypt regeneration following injury

AU - Ottewell, Penelope D

AU - Duckworth, Carrie A

AU - Varro, Andrea

AU - Dimaline, Rod

AU - Wang, Timothy C

AU - Watson, Alastair J M

AU - Dockray, Graham J

AU - Pritchard, D Mark

PY - 2006/4

Y1 - 2006/4

N2 - A number of growth factors affect the regeneration of intestinal epithelia following injury, but the effects of amidated gastrin have not previously been assessed. We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli.

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KW - Animals

KW - Benzodiazepinones

KW - Cell Line

KW - Cell Proliferation

KW - Colitis

KW - Dextran Sulfate

KW - Enteritis

KW - Enzyme Inhibitors

KW - Fluorouracil

KW - Gamma Rays

KW - Gastrins

KW - Growth Substances

KW - Intestinal Mucosa

KW - Mice

KW - Mice, Inbred Strains

KW - Mice, Transgenic

KW - Omeprazole

KW - Phenylurea Compounds

KW - Proton Pump Inhibitors

KW - Receptor, Cholecystokinin B

KW - Regeneration

KW - Wounds and Injuries

U2 - 10.1053/j.gastro.2005.12.033

DO - 10.1053/j.gastro.2005.12.033

M3 - Article

C2 - 16618411

VL - 130

SP - 1169

EP - 1180

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 4

ER -