Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

Heleen M van den Bosch; Meike Bünger; Philip J de Groot; Jolanda van der Meijde; Guido J E J Hooiveld; Michael Müller

doi:10.1186/1471-2164-8-267

Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

Heleen M van den Bosch, Meike Bünger, Philip J de Groot, Jolanda van der Meijde, Guido J E J Hooiveld, Michael Müller

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARalpha may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR.

Original language	English
Article number	267
Journal	BMC Genomics
Volume	8
DOIs	https://doi.org/10.1186/1471-2164-8-267
Publication status	Published - 7 Aug 2007

Keywords

ATP-Binding Cassette Transporters
Animals
Fasting
Gene Expression Profiling
Gene Expression Regulation
Small Intestine
Metabolic Networks and Pathways
Mice
Oligonucleotide Array Sequence Analysis
Organic Anion Transporters
PPAR alpha
Time Factors

Access to Document

10.1186/1471-2164-8-267Licence: CC BY

Cite this

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title = "Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting",

abstract = "Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARalpha may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR.",

keywords = "ATP-Binding Cassette Transporters, Animals, Fasting, Gene Expression Profiling, Gene Expression Regulation, Small Intestine, Metabolic Networks and Pathways, Mice, Oligonucleotide Array Sequence Analysis, Organic Anion Transporters, PPAR alpha, Time Factors",

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T1 - Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting

AU - van den Bosch, Heleen M

AU - Bünger, Meike

AU - de Groot, Philip J

AU - van der Meijde, Jolanda

AU - Hooiveld, Guido J E J

AU - Müller, Michael

N1 - © 2007 van den Bosch et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2007/8/7

Y1 - 2007/8/7

N2 - Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARalpha may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR.

AB - Fasting has dramatic effects on small intestinal transport function. However, little is known on expression of intestinal transport and phase I/II metabolism genes during fasting and the role the fatty acid-activated transcription factor PPARalpha may play herein. We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR.

KW - ATP-Binding Cassette Transporters

KW - Animals

KW - Fasting

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Small Intestine

KW - Metabolic Networks and Pathways

KW - Mice

KW - Oligonucleotide Array Sequence Analysis

KW - Organic Anion Transporters

KW - PPAR alpha

KW - Time Factors

U2 - 10.1186/1471-2164-8-267

DO - 10.1186/1471-2164-8-267

M3 - Article

C2 - 17683626

VL - 8

JO - BMC Genomics

JF - BMC Genomics

SN - 1471-2164

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