Generalizing results of randomized trials to clinical practice: reliability and cautions

Marcus Flather, Nicola Delahunty, Julian Collinson

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.
Original languageEnglish
Pages (from-to)508-12
Number of pages5
JournalClinical Trials
Issue number6
Publication statusPublished - 2006


  • Humans
  • Patient Compliance
  • Patient Selection
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Research Design

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