Generalizing results of randomized trials to clinical practice: reliability and cautions

Marcus Flather; Nicola Delahunty; Julian Collinson

doi:10.1177/1740774506073464

Generalizing results of randomized trials to clinical practice: reliability and cautions

Marcus Flather, Nicola Delahunty, Julian Collinson

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.

Original language	English
Pages (from-to)	508-12
Number of pages	5
Journal	Clinical Trials
Volume	3
Issue number	6
DOIs	https://doi.org/10.1177/1740774506073464
Publication status	Published - 2006

Keywords

Humans
Patient Compliance
Patient Selection
Randomized Controlled Trials as Topic
Reproducibility of Results
Research Design

Access to Document

10.1177/1740774506073464

Cite this

@article{658fc0f200b940169aa52dd7b7a6edfb,

title = "Generalizing results of randomized trials to clinical practice: reliability and cautions",

abstract = "Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.",

keywords = "Humans, Patient Compliance, Patient Selection, Randomized Controlled Trials as Topic, Reproducibility of Results, Research Design",

author = "Marcus Flather and Nicola Delahunty and Julian Collinson",

year = "2006",

doi = "10.1177/1740774506073464",

language = "English",

volume = "3",

pages = "508--12",

journal = "Clinical Trials",

issn = "1740-7745",

publisher = "Sage Publications",

number = "6",

}

TY - JOUR

T1 - Generalizing results of randomized trials to clinical practice

T2 - reliability and cautions

AU - Flather, Marcus

AU - Delahunty, Nicola

AU - Collinson, Julian

PY - 2006

Y1 - 2006

N2 - Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.

AB - Well designed randomized controlled trials provide reliable evidence of treatment effects, but there is no consensus on how best to apply these results to clinical practice. The main concerns are that populations enrolled in trials are more selected than those treated in a clinical setting, and whether the treatment effects observed in trials will also be observed in clinical practice.

KW - Humans

KW - Patient Compliance

KW - Patient Selection

KW - Randomized Controlled Trials as Topic

KW - Reproducibility of Results

KW - Research Design

U2 - 10.1177/1740774506073464

DO - 10.1177/1740774506073464

M3 - Article

C2 - 17170034

VL - 3

SP - 508

EP - 512

JO - Clinical Trials

JF - Clinical Trials

SN - 1740-7745

IS - 6

ER -