Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Rebecca J. M. Goss, Simon E. Lanceron, Nicola J. Wise, Steven J. Moss

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.
Original languageEnglish
Pages (from-to)4071-4073
Number of pages3
JournalOrganic & Biomolecular Chemistry
Volume4
Issue number22
Early online date16 Oct 2006
DOIs
Publication statusPublished - 2006

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