Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Rebecca J. M. Goss; Simon E. Lanceron; Nicola J. Wise; Steven J. Moss

doi:10.1039/b614519c

Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Rebecca J. M. Goss, Simon E. Lanceron, Nicola J. Wise, Steven J. Moss

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

Original language	English
Pages (from-to)	4071-4073
Number of pages	3
Journal	Organic & Biomolecular Chemistry
Volume	4
Issue number	22
Early online date	16 Oct 2006
DOIs	https://doi.org/10.1039/b614519c
Publication status	Published - 2006

Access to Document

10.1039/b614519c

Cite this

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title = "Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids",

abstract = "We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.",

author = "Goss, {Rebecca J. M.} and Lanceron, {Simon E.} and Wise, {Nicola J.} and Moss, {Steven J.}",

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AU - Goss, Rebecca J. M.

AU - Lanceron, Simon E.

AU - Wise, Nicola J.

AU - Moss, Steven J.

PY - 2006

Y1 - 2006

N2 - We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

AB - We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

U2 - 10.1039/b614519c

DO - 10.1039/b614519c

M3 - Article

VL - 4

SP - 4071

EP - 4073

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1477-0520

IS - 22

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