Generation of Leaf Shape Through Early Patterns of Growth and Tissue Polarity

Erika E. Kuchen, Samantha Fox, Pierre Barbier de Reuille, Richard Kennaway, Sandra Bensmihen, Jerome Avondo, Grant M. Calder, Paul Southam, Sarah Robinson, Andrew Bangham, Enrico Coen

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

A major challenge in biology is to understand how buds comprising a few cells can give rise to complex plant and animal appendages like leaves or limbs. We address this problem through a combination of time-lapse imaging, clonal analysis, and computational modeling. We arrive at a model that shows how leaf shape can arise through feedback between early patterns of oriented growth and tissue deformation. Experimental tests through partial leaf ablation support this model and allow reevaluation of previous experimental studies. Our model allows a range of observed leaf shapes to be generated and predicts observed clone patterns in different species. Thus, our experimentally validated model may underlie the development and evolution of diverse organ shapes.
Original languageEnglish
Pages (from-to)1092-1096
Number of pages5
JournalScience
Volume335
Issue number6072
DOIs
Publication statusPublished - 2 Mar 2012

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