Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease

Lesley Jones; Peter A. Holmans; Marian L. Hamshere; Denise Harold; Valentina Moskvina; Dobril Ivanov; Andrew Pocklington; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Jaspreet Singh Pahwa; Nicola Jones; Alexandra Stretton; Angharad R. Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K. Lupton; Carol Brayne; David C. Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S. Brown; Peter A. Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; David Mann; A. David Smith; Seth Love; Patrick G. Kehoe; Simon Mead; Nick Fox; Martin Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Hendrik van den Bussche; Isabella Heuser; Oliver Peters; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Frölich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison M. Goate; John S. K. Kauwe; Carlos Cruchaga; Petra Nowotny; John C. Morris; Kevin Mayo; Gill Livingston; Nicholas J. Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panos Deloukas; Ammar Al-Chalabi; Christopher E. Shaw; Andrew B. Singleton; Rita Guerreiro; Thomas W. Mühleisen; Markus M. Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H.-Erich Wichmann; Eckhard Rüther; Minerva M. Carrasquillo; V. Shane Pankratz; Steven G. Younkin; John Hardy; Michael C. O'Donovan; Michael J. Owen; Julie Williams

doi:10.1371/journal.pone.0013950

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease

Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol BrayneDavid C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

343 Citations (Scopus)

Original language	English
Article number	e13950
Journal	PLoS One
Volume	5
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0013950
Publication status	Published - 15 Nov 2010

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10.1371/journal.pone.0013950Licence: CC BY

Cite this

Jones, L., Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. S., Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., ... Williams, J. (2010). Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease. PLoS One, 5(11), Article e13950. https://doi.org/10.1371/journal.pone.0013950

@article{1abc8668ad144479bdc41d8472121ecf,

title = "Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease",

author = "Lesley Jones and Holmans, {Peter A.} and Hamshere, {Marian L.} and Denise Harold and Valentina Moskvina and Dobril Ivanov and Andrew Pocklington and Richard Abraham and Paul Hollingworth and Rebecca Sims and Amy Gerrish and Pahwa, {Jaspreet Singh} and Nicola Jones and Alexandra Stretton and Morgan, {Angharad R.} and Simon Lovestone and John Powell and Petroula Proitsi and Lupton, {Michelle K.} and Carol Brayne and Rubinsztein, {David C.} and Michael Gill and Brian Lawlor and Aoibhinn Lynch and Kevin Morgan and Brown, {Kristelle S.} and Passmore, {Peter A.} and David Craig and Bernadette McGuinness and Stephen Todd and Clive Holmes and David Mann and Smith, {A. David} and Seth Love and Kehoe, {Patrick G.} and Simon Mead and Nick Fox and Martin Rossor and John Collinge and Wolfgang Maier and Frank Jessen and Britta Sch{\"u}rmann and {van den Bussche}, Hendrik and Isabella Heuser and Oliver Peters and Johannes Kornhuber and Jens Wiltfang and Martin Dichgans and Lutz Fr{\"o}lich and Harald Hampel and Michael H{\"u}ll and Dan Rujescu and Goate, {Alison M.} and Kauwe, {John S. K.} and Carlos Cruchaga and Petra Nowotny and Morris, {John C.} and Kevin Mayo and Gill Livingston and Bass, {Nicholas J.} and Hugh Gurling and Andrew McQuillin and Rhian Gwilliam and Panos Deloukas and Ammar Al-Chalabi and Shaw, {Christopher E.} and Singleton, {Andrew B.} and Rita Guerreiro and M{\"u}hleisen, {Thomas W.} and N{\"o}then, {Markus M.} and Susanne Moebus and Karl-Heinz J{\"o}ckel and Norman Klopp and H.-Erich Wichmann and Eckhard R{\"u}ther and Carrasquillo, {Minerva M.} and Pankratz, {V. Shane} and Younkin, {Steven G.} and John Hardy and O'Donovan, {Michael C.} and Owen, {Michael J.} and Julie Williams",

note = "{\textcopyright} 2010 Jones et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2010",

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language = "English",

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Jones, L, Holmans, PA, Hamshere, ML, Harold, D, Moskvina, V, Ivanov, D, Pocklington, A, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Pahwa, JS, Jones, N, Stretton, A, Morgan, AR, Lovestone, S, Powell, J, Proitsi, P, Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, KS, Passmore, PA, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, AD, Love, S, Kehoe, PG, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schürmann, B, van den Bussche, H, Heuser, I, Peters, O, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, AM, Kauwe, JSK, Cruchaga, C, Nowotny, P, Morris, JC, Mayo, K, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, CE, Singleton, AB, Guerreiro, R, Mühleisen, TW, Nöthen, MM, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Rüther, E, Carrasquillo, MM, Pankratz, VS, Younkin, SG, Hardy, J, O'Donovan, MC, Owen, MJ & Williams, J 2010, 'Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease', PLoS One, vol. 5, no. 11, e13950. https://doi.org/10.1371/journal.pone.0013950

TY - JOUR

T1 - Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's Disease

AU - Jones, Lesley

AU - Holmans, Peter A.

AU - Hamshere, Marian L.

AU - Harold, Denise

AU - Moskvina, Valentina

AU - Ivanov, Dobril

AU - Pocklington, Andrew

AU - Abraham, Richard

AU - Hollingworth, Paul

AU - Sims, Rebecca

AU - Gerrish, Amy

AU - Pahwa, Jaspreet Singh

AU - Jones, Nicola

AU - Stretton, Alexandra

AU - Morgan, Angharad R.

AU - Lovestone, Simon

AU - Powell, John

AU - Proitsi, Petroula

AU - Lupton, Michelle K.

AU - Brayne, Carol

AU - Rubinsztein, David C.

AU - Gill, Michael

AU - Lawlor, Brian

AU - Lynch, Aoibhinn

AU - Morgan, Kevin

AU - Brown, Kristelle S.

AU - Passmore, Peter A.

AU - Craig, David

AU - McGuinness, Bernadette

AU - Todd, Stephen

AU - Holmes, Clive

AU - Mann, David

AU - Smith, A. David

AU - Love, Seth

AU - Kehoe, Patrick G.

AU - Mead, Simon

AU - Fox, Nick

AU - Rossor, Martin

AU - Collinge, John

AU - Maier, Wolfgang

AU - Jessen, Frank

AU - Schürmann, Britta

AU - van den Bussche, Hendrik

AU - Heuser, Isabella

AU - Peters, Oliver

AU - Kornhuber, Johannes

AU - Wiltfang, Jens

AU - Dichgans, Martin

AU - Frölich, Lutz

AU - Hampel, Harald

AU - Hüll, Michael

AU - Rujescu, Dan

AU - Goate, Alison M.

AU - Kauwe, John S. K.

AU - Cruchaga, Carlos

AU - Nowotny, Petra

AU - Morris, John C.

AU - Mayo, Kevin

AU - Livingston, Gill

AU - Bass, Nicholas J.

AU - Gurling, Hugh

AU - McQuillin, Andrew

AU - Gwilliam, Rhian

AU - Deloukas, Panos

AU - Al-Chalabi, Ammar

AU - Shaw, Christopher E.

AU - Singleton, Andrew B.

AU - Guerreiro, Rita

AU - Mühleisen, Thomas W.

AU - Nöthen, Markus M.

AU - Moebus, Susanne

AU - Jöckel, Karl-Heinz

AU - Klopp, Norman

AU - Wichmann, H.-Erich

AU - Rüther, Eckhard

AU - Carrasquillo, Minerva M.

AU - Pankratz, V. Shane

AU - Younkin, Steven G.

AU - Hardy, John

AU - O'Donovan, Michael C.

AU - Owen, Michael J.

AU - Williams, Julie

N1 - © 2010 Jones et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2010/11/15

Y1 - 2010/11/15

U2 - 10.1371/journal.pone.0013950

DO - 10.1371/journal.pone.0013950

M3 - Article

SN - 1932-6203

VL - 5

JO - PLoS One

JF - PLoS One

IS - 11

M1 - e13950

ER -