Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

John R. B. Perry; Michael N. Weedon; Claudia Langenberg; Anne U. Jackson; Valeriya Lyssenko; Thomas Sparsø; Gudmar Thorleifsson; Harald Grallert; Luigi Ferrucci; Marcello Maggio; Giuseppe Paolisso; Mark Walker; Colin N. A. Palmer; Felicity Payne; Elizabeth Young; Christian Herder; Narisu Narisu; Mario A. Morken; Lori L. Bonnycastle; Katharine R. Owen; Beverley Shields; Beatrice Knight; Amanda Bennett; Christopher J. Groves; Aimo Ruokonen; Marjo Riitta Jarvelin; Ewan Pearson; Laura Pascoe; Ele Ferrannini; Stefan R. Bornstein; Heather M. Stringham; Laura J. Scott; Johanna Kuusisto; Peter Nilsson; Malin Neptin; Anette P. Gjesing; Charlotta Pisinger; Torsten Lauritzen; Annelli Sandbaek; Mike Sampson; M. Ele Zeggini; Cecilia M. Lindgren; Valgerdur Steinthorsdottir; Unnur Thorsteinsdottir; Torben Hansen; Peter Schwarz; Thomas Illig; Markku Laakso; Kari Stefansson; Andrew D. Morris; Leif Groop; Oluf Pedersen; Michael Boehnke; Inês Barroso; Nicholas J. Wareham; Andrew T. Hattersley; Mark I. McCarthy; Timothy M. Frayling

doi:10.1093/hmg/ddp522

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

John R. B. Perry, Michael N. Weedon, Claudia Langenberg, Anne U. Jackson, Valeriya Lyssenko, Thomas Sparsø, Gudmar Thorleifsson, Harald Grallert, Luigi Ferrucci, Marcello Maggio, Giuseppe Paolisso, Mark Walker, Colin N. A. Palmer, Felicity Payne, Elizabeth Young, Christian Herder, Narisu Narisu, Mario A. Morken, Lori L. Bonnycastle, Katharine R. OwenBeverley Shields, Beatrice Knight, Amanda Bennett, Christopher J. Groves, Aimo Ruokonen, Marjo Riitta Jarvelin, Ewan Pearson, Laura Pascoe, Ele Ferrannini, Stefan R. Bornstein, Heather M. Stringham, Laura J. Scott, Johanna Kuusisto, Peter Nilsson, Malin Neptin, Anette P. Gjesing, Charlotta Pisinger, Torsten Lauritzen, Annelli Sandbaek, Mike Sampson, M. Ele Zeggini, Cecilia M. Lindgren, Valgerdur Steinthorsdottir, Unnur Thorsteinsdottir, Torben Hansen, Peter Schwarz, Thomas Illig, Markku Laakso, Kari Stefansson, Andrew D. Morris, Leif Groop, Oluf Pedersen, Michael Boehnke, Inês Barroso, Nicholas J. Wareham, Andrew T. Hattersley, Mark I. McCarthy, Timothy M. Frayling

Research output: Contribution to journal › Article › peer-review

168 Citations (Scopus)

Original language	English
Pages (from-to)	535-544
Number of pages	10
Journal	Human Molecular Genetics
Volume	19
Issue number	3
DOIs	https://doi.org/10.1093/hmg/ddp522
Publication status	Published - 2010

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Cite this

Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., Paolisso, G., Walker, M., Palmer, C. N. A., Payne, F., Young, E., Herder, C., Narisu, N., Morken, M. A., Bonnycastle, L. L., ... Frayling, T. M. (2010). Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Human Molecular Genetics, 19(3), 535-544. https://doi.org/10.1093/hmg/ddp522

Perry, John R. B. ; Weedon, Michael N. ; Langenberg, Claudia ; Jackson, Anne U. ; Lyssenko, Valeriya ; Sparsø, Thomas ; Thorleifsson, Gudmar ; Grallert, Harald ; Ferrucci, Luigi ; Maggio, Marcello ; Paolisso, Giuseppe ; Walker, Mark ; Palmer, Colin N. A. ; Payne, Felicity ; Young, Elizabeth ; Herder, Christian ; Narisu, Narisu ; Morken, Mario A. ; Bonnycastle, Lori L. ; Owen, Katharine R. ; Shields, Beverley ; Knight, Beatrice ; Bennett, Amanda ; Groves, Christopher J. ; Ruokonen, Aimo ; Jarvelin, Marjo Riitta ; Pearson, Ewan ; Pascoe, Laura ; Ferrannini, Ele ; Bornstein, Stefan R. ; Stringham, Heather M. ; Scott, Laura J. ; Kuusisto, Johanna ; Nilsson, Peter ; Neptin, Malin ; Gjesing, Anette P. ; Pisinger, Charlotta ; Lauritzen, Torsten ; Sandbaek, Annelli ; Sampson, Mike ; Zeggini, M. Ele ; Lindgren, Cecilia M. ; Steinthorsdottir, Valgerdur ; Thorsteinsdottir, Unnur ; Hansen, Torben ; Schwarz, Peter ; Illig, Thomas ; Laakso, Markku ; Stefansson, Kari ; Morris, Andrew D. ; Groop, Leif ; Pedersen, Oluf ; Boehnke, Michael ; Barroso, Inês ; Wareham, Nicholas J. ; Hattersley, Andrew T. ; McCarthy, Mark I. ; Frayling, Timothy M. / Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. In: Human Molecular Genetics. 2010 ; Vol. 19, No. 3. pp. 535-544.

@article{1bb38a7ed8444f1aa41902174cc61fdc,

title = "Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes",

author = "Perry, {John R. B.} and Weedon, {Michael N.} and Claudia Langenberg and Jackson, {Anne U.} and Valeriya Lyssenko and Thomas Spars{\o} and Gudmar Thorleifsson and Harald Grallert and Luigi Ferrucci and Marcello Maggio and Giuseppe Paolisso and Mark Walker and Palmer, {Colin N. A.} and Felicity Payne and Elizabeth Young and Christian Herder and Narisu Narisu and Morken, {Mario A.} and Bonnycastle, {Lori L.} and Owen, {Katharine R.} and Beverley Shields and Beatrice Knight and Amanda Bennett and Groves, {Christopher J.} and Aimo Ruokonen and Jarvelin, {Marjo Riitta} and Ewan Pearson and Laura Pascoe and Ele Ferrannini and Bornstein, {Stefan R.} and Stringham, {Heather M.} and Scott, {Laura J.} and Johanna Kuusisto and Peter Nilsson and Malin Neptin and Gjesing, {Anette P.} and Charlotta Pisinger and Torsten Lauritzen and Annelli Sandbaek and Mike Sampson and Zeggini, {M. Ele} and Lindgren, {Cecilia M.} and Valgerdur Steinthorsdottir and Unnur Thorsteinsdottir and Torben Hansen and Peter Schwarz and Thomas Illig and Markku Laakso and Kari Stefansson and Morris, {Andrew D.} and Leif Groop and Oluf Pedersen and Michael Boehnke and In{\^e}s Barroso and Wareham, {Nicholas J.} and Hattersley, {Andrew T.} and McCarthy, {Mark I.} and Frayling, {Timothy M.}",

year = "2010",

doi = "10.1093/hmg/ddp522",

language = "English",

volume = "19",

pages = "535--544",

journal = "Human Molecular Genetics",

issn = "0964-6906",

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Perry, JRB, Weedon, MN, Langenberg, C, Jackson, AU, Lyssenko, V, Sparsø, T, Thorleifsson, G, Grallert, H, Ferrucci, L, Maggio, M, Paolisso, G, Walker, M, Palmer, CNA, Payne, F, Young, E, Herder, C, Narisu, N, Morken, MA, Bonnycastle, LL, Owen, KR, Shields, B, Knight, B, Bennett, A, Groves, CJ, Ruokonen, A, Jarvelin, MR, Pearson, E, Pascoe, L, Ferrannini, E, Bornstein, SR, Stringham, HM, Scott, LJ, Kuusisto, J, Nilsson, P, Neptin, M, Gjesing, AP, Pisinger, C, Lauritzen, T, Sandbaek, A, Sampson, M, Zeggini, ME, Lindgren, CM, Steinthorsdottir, V, Thorsteinsdottir, U, Hansen, T, Schwarz, P, Illig, T, Laakso, M, Stefansson, K, Morris, AD, Groop, L, Pedersen, O, Boehnke, M, Barroso, I, Wareham, NJ, Hattersley, AT, McCarthy, MI & Frayling, TM 2010, 'Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes', Human Molecular Genetics, vol. 19, no. 3, pp. 535-544. https://doi.org/10.1093/hmg/ddp522

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. / Perry, John R. B.; Weedon, Michael N.; Langenberg, Claudia; Jackson, Anne U.; Lyssenko, Valeriya; Sparsø, Thomas; Thorleifsson, Gudmar; Grallert, Harald; Ferrucci, Luigi; Maggio, Marcello; Paolisso, Giuseppe; Walker, Mark; Palmer, Colin N. A.; Payne, Felicity; Young, Elizabeth; Herder, Christian; Narisu, Narisu; Morken, Mario A.; Bonnycastle, Lori L.; Owen, Katharine R.; Shields, Beverley; Knight, Beatrice; Bennett, Amanda; Groves, Christopher J.; Ruokonen, Aimo; Jarvelin, Marjo Riitta; Pearson, Ewan; Pascoe, Laura; Ferrannini, Ele; Bornstein, Stefan R.; Stringham, Heather M.; Scott, Laura J.; Kuusisto, Johanna; Nilsson, Peter; Neptin, Malin; Gjesing, Anette P.; Pisinger, Charlotta; Lauritzen, Torsten; Sandbaek, Annelli; Sampson, Mike; Zeggini, M. Ele; Lindgren, Cecilia M.; Steinthorsdottir, Valgerdur; Thorsteinsdottir, Unnur; Hansen, Torben; Schwarz, Peter; Illig, Thomas; Laakso, Markku; Stefansson, Kari; Morris, Andrew D.; Groop, Leif; Pedersen, Oluf; Boehnke, Michael; Barroso, Inês; Wareham, Nicholas J.; Hattersley, Andrew T.; McCarthy, Mark I.; Frayling, Timothy M.

In: Human Molecular Genetics, Vol. 19, No. 3, 2010, p. 535-544.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

AU - Perry, John R. B.

AU - Weedon, Michael N.

AU - Langenberg, Claudia

AU - Jackson, Anne U.

AU - Lyssenko, Valeriya

AU - Sparsø, Thomas

AU - Thorleifsson, Gudmar

AU - Grallert, Harald

AU - Ferrucci, Luigi

AU - Maggio, Marcello

AU - Paolisso, Giuseppe

AU - Walker, Mark

AU - Palmer, Colin N. A.

AU - Payne, Felicity

AU - Young, Elizabeth

AU - Herder, Christian

AU - Narisu, Narisu

AU - Morken, Mario A.

AU - Bonnycastle, Lori L.

AU - Owen, Katharine R.

AU - Shields, Beverley

AU - Knight, Beatrice

AU - Bennett, Amanda

AU - Groves, Christopher J.

AU - Ruokonen, Aimo

AU - Jarvelin, Marjo Riitta

AU - Pearson, Ewan

AU - Pascoe, Laura

AU - Ferrannini, Ele

AU - Bornstein, Stefan R.

AU - Stringham, Heather M.

AU - Scott, Laura J.

AU - Kuusisto, Johanna

AU - Nilsson, Peter

AU - Neptin, Malin

AU - Gjesing, Anette P.

AU - Pisinger, Charlotta

AU - Lauritzen, Torsten

AU - Sandbaek, Annelli

AU - Sampson, Mike

AU - Zeggini, M. Ele

AU - Lindgren, Cecilia M.

AU - Steinthorsdottir, Valgerdur

AU - Thorsteinsdottir, Unnur

AU - Hansen, Torben

AU - Schwarz, Peter

AU - Illig, Thomas

AU - Laakso, Markku

AU - Stefansson, Kari

AU - Morris, Andrew D.

AU - Groop, Leif

AU - Pedersen, Oluf

AU - Boehnke, Michael

AU - Barroso, Inês

AU - Wareham, Nicholas J.

AU - Hattersley, Andrew T.

AU - McCarthy, Mark I.

AU - Frayling, Timothy M.

PY - 2010

Y1 - 2010

U2 - 10.1093/hmg/ddp522

DO - 10.1093/hmg/ddp522

M3 - Article

VL - 19

SP - 535

EP - 544

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 3

ER -