Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

P. Harvie; S. J. Ostlere; J. Teh; E. G. McNally; K. E. Clipsham; B. J. Burston; T. C. B. Pollard; A. J. Carr

doi:10.1302/0301-620X.86B5.14747

Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

P. Harvie, S. J. Ostlere, J. Teh, E. G. McNally, K. E. Clipsham, B. J. Burston, T. C. B. Pollard, A. J. Carr

Norwich Medical School

Research output: Contribution to journal › Article

132 Citations (Scopus)

Abstract

From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63).

The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

Original language	English
Pages (from-to)	696-700
Number of pages	5
Journal	Journal of Bone and Joint Surgery-British
Volume	86-B
Issue number	5
DOIs	https://doi.org/10.1302/0301-620X.86B5.14747
Publication status	Published - 1 Jul 2004

Access to Document

10.1302/0301-620X.86B5.14747

Cite this

@article{b6e87860bf474bbf824291028d88e143,

title = "Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear",

abstract = "From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.",

author = "P. Harvie and Ostlere, {S. J.} and J. Teh and McNally, {E. G.} and Clipsham, {K. E.} and Burston, {B. J.} and Pollard, {T. C. B.} and Carr, {A. J.}",

year = "2004",

month = jul,

day = "1",

doi = "10.1302/0301-620X.86B5.14747",

language = "English",

volume = "86-B",

pages = "696--700",

journal = "Journal of Bone and Joint Surgery-British",

number = "5",

}

TY - JOUR

T1 - Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

AU - Harvie, P.

AU - Ostlere, S. J.

AU - Teh, J.

AU - McNally, E. G.

AU - Clipsham, K. E.

AU - Burston, B. J.

AU - Pollard, T. C. B.

AU - Carr, A. J.

PY - 2004/7/1

Y1 - 2004/7/1

N2 - From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

AB - From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

U2 - 10.1302/0301-620X.86B5.14747

DO - 10.1302/0301-620X.86B5.14747

M3 - Article

VL - 86-B

SP - 696

EP - 700

JO - Journal of Bone and Joint Surgery-British

JF - Journal of Bone and Joint Surgery-British

IS - 5

ER -