Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

P. Harvie; S. J. Ostlere; J. Teh; E. G. McNally; K. E. Clipsham; B. J. Burston; T. C. B. Pollard; A. J. Carr

doi:10.1302/0301-620X.86B5.14747

Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

P. Harvie
, S. J. Ostlere
, J. Teh
, E. G. McNally
, K. E. Clipsham
, B. J. Burston
, T. C. B. Pollard
, A. J. Carr

Norwich Medical School

Research output: Contribution to journal › Article

144 Citations (Scopus)

Abstract

From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63).

The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

Original language	English
Pages (from-to)	696-700
Number of pages	5
Journal	Journal of Bone and Joint Surgery-British
Volume	86-B
Issue number	5
DOIs	https://doi.org/10.1302/0301-620X.86B5.14747
Publication status	Published - 1 Jul 2004

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10.1302/0301-620X.86B5.14747

Cite this

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title = "Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear",

abstract = "From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95\% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95\% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.",

author = "P. Harvie and Ostlere, \{S. J.\} and J. Teh and McNally, \{E. G.\} and Clipsham, \{K. E.\} and Burston, \{B. J.\} and Pollard, \{T. C. B.\} and Carr, \{A. J.\}",

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T1 - Genetic influences in the aetiology of tears of the rotator cuff: Sibling risk of a full-thickness tear

AU - Harvie, P.

AU - Ostlere, S. J.

AU - Teh, J.

AU - McNally, E. G.

AU - Clipsham, K. E.

AU - Burston, B. J.

AU - Pollard, T. C. B.

AU - Carr, A. J.

PY - 2004/7/1

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N2 - From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

AB - From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63). The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.

U2 - 10.1302/0301-620X.86B5.14747

DO - 10.1302/0301-620X.86B5.14747

M3 - Article

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SP - 696

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JO - Journal of Bone and Joint Surgery-British

JF - Journal of Bone and Joint Surgery-British

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