TY - JOUR
T1 - Genetic variants of FADS gene cluster, plasma LC-PUFA levels and the association with cognitive function of under-two-year-old Sasaknese Indonesian children
AU - Fahmida, Umi
AU - Htet, Min Kyaw
AU - Adhiyanto, Chris
AU - Kolopaking, Risatianti
AU - Yudisti, Miza Agria
AU - Maududi, Allay
AU - Suryandari, Dwi Anita
AU - Dillon, Drupadi
AU - Afman, Lydia
AU - Müller, Michael
PY - 2015/6/1
Y1 - 2015/6/1
N2 - BACKGROUND/AIMS: Long-chain polyunsaturated fatty acids (LC-PUFA) are regarded as essential for child cognition. Genetic variation in fatty acid (FA) desaturase enzyme (FADS) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function. This study aimed to identify the distribution of genetic variant (genotype) SNP rs174468 and to assess plasma FA and developmental outcome by the genotype among under-2 year old Sasaknese Indonesian children.METHODS: Data was collected at baseline of a randomized trial (NUPICO, clinicaltrials.gov NCT01504633) in East Lombok district, Indonesia. Breastfed, 12- 17 month old children were recruited and 240 subjects were included in the study. Child cognition was assessed as Bayley Mental Developmental Index (MDI).RESULTS: From 206 subjects whose blood samples can be collected, only two genotypes were found (90.3% GG homozygotes, 9.7% AG heterozygotes), and minor allele AG was significantly associated with higher level of arachidonic acid (20:4 n-6), n-6 LC-PUFA and FADS1 index. MDI score was associated with a FADS2 index (DHA:EPA ratio) but not genotype (Adjusted R-square= 0.043).CONCLUSIONS: FADS2 index was associated with cognitive function. No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight.
AB - BACKGROUND/AIMS: Long-chain polyunsaturated fatty acids (LC-PUFA) are regarded as essential for child cognition. Genetic variation in fatty acid (FA) desaturase enzyme (FADS) has been recognized as an important effect modifier in the relation between LC-PUFA and child cognitive function. This study aimed to identify the distribution of genetic variant (genotype) SNP rs174468 and to assess plasma FA and developmental outcome by the genotype among under-2 year old Sasaknese Indonesian children.METHODS: Data was collected at baseline of a randomized trial (NUPICO, clinicaltrials.gov NCT01504633) in East Lombok district, Indonesia. Breastfed, 12- 17 month old children were recruited and 240 subjects were included in the study. Child cognition was assessed as Bayley Mental Developmental Index (MDI).RESULTS: From 206 subjects whose blood samples can be collected, only two genotypes were found (90.3% GG homozygotes, 9.7% AG heterozygotes), and minor allele AG was significantly associated with higher level of arachidonic acid (20:4 n-6), n-6 LC-PUFA and FADS1 index. MDI score was associated with a FADS2 index (DHA:EPA ratio) but not genotype (Adjusted R-square= 0.043).CONCLUSIONS: FADS2 index was associated with cognitive function. No difference was found between children with GG and AG genotypes who were all breastfed and not low birth weight.
KW - Alleles
KW - Arachidonic Acid/blood
KW - Cognition/physiology
KW - Fatty Acid Desaturases/genetics
KW - Fatty Acids, Omega-6/blood
KW - Fatty Acids, Unsaturated/blood
KW - Female
KW - Genetic Variation/genetics
KW - Genotype
KW - Humans
KW - Indonesia
KW - Infant
KW - Male
KW - Multigene Family/genetics
UR - http://apjcn.nhri.org.tw/server/APJCN/24/2/323.pdf
U2 - 10.6133/apjcn.2015.24.2.17
DO - 10.6133/apjcn.2015.24.2.17
M3 - Article
C2 - 26078250
VL - 24
SP - 323
EP - 328
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
SN - 0964-7058
IS - 2
ER -