Genetic variation in myosin IXB is associated with ulcerative colitis

Adriaan A van Bodegraven, Christine R Curley, Karen A Hunt, Alienke J Monsuur, Ronald K Linskens, Clive M Onnie, J Bart A Crusius, Vito Annese, Anna Latiano, Mark S Silverberg, Alain Bitton, Sheila A Fisher, A Hilary Steinhart, Alastair Forbes, Jeremy Sanderson, Natalie J Prescott, David P Strachan, Raymond J Playford, Christopher G Mathew, Cisca WijmengaMark J Daly, John D Rioux, David A van Heel

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role for MYO9B variation in inflammatory bowel disease.
Original languageEnglish
Pages (from-to)1768-74
Number of pages7
JournalGastroenterology
Volume131
Issue number6
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Child
  • Cohort Studies
  • Colitis, Ulcerative
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myosins
  • Polymorphism, Single Nucleotide

Cite this