Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease

K King; A Moody; S A Fisher; M M Mirza; A P Cuthbert; J Hampe; A Sutherland-Craggs; J Sanderson; A J MacPherson; A Forbes; J Mansfield; S Schreiber; C M Lewis; C G Mathew

doi:10.1046/j.1365-2370.2003.00387.x

Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease

K King, A Moody, S A Fisher, M M Mirza, A P Cuthbert, J Hampe, A Sutherland-Craggs, J Sanderson, A J MacPherson, A Forbes, J Mansfield, S Schreiber, C M Lewis, C G Mathew

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of IGSF6 for single nucleotide polymorphisms (SNPs) detected four novel SNPs, and validated three of six SNPs listed in the international SNP database (dbSNP). The seven SNPs in IGSF6 formed five distinct linkage disequilibrium groups. There was no evidence for association of the common SNPs with disease in a large cohort of patients with IBD. The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders.

Original language	English
Pages (from-to)	187-190
Number of pages	4
Journal	European Journal of Immunogenetics
Volume	30
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2370.2003.00387.x
Publication status	Published - Jun 2003

Keywords

Antigens, CD8
Carrier Proteins
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Genetic Predisposition to Disease
Genetic Variation
Humans
Immunoglobulins
Inflammatory Bowel Diseases
Intracellular Signaling Peptides and Proteins
Linkage Disequilibrium
Nod2 Signaling Adaptor Protein
Pedigree
Polymorphism, Single Nucleotide

Access to Document

10.1046/j.1365-2370.2003.00387.x

Cite this

King, K., Moody, A., Fisher, S. A., Mirza, M. M., Cuthbert, A. P., Hampe, J., Sutherland-Craggs, A., Sanderson, J., MacPherson, A. J., Forbes, A., Mansfield, J., Schreiber, S., Lewis, C. M., & Mathew, C. G. (2003). Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. European Journal of Immunogenetics, 30(3), 187-190. https://doi.org/10.1046/j.1365-2370.2003.00387.x

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title = "Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease",

abstract = "The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of IGSF6 for single nucleotide polymorphisms (SNPs) detected four novel SNPs, and validated three of six SNPs listed in the international SNP database (dbSNP). The seven SNPs in IGSF6 formed five distinct linkage disequilibrium groups. There was no evidence for association of the common SNPs with disease in a large cohort of patients with IBD. The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders.",

keywords = "Antigens, CD8, Carrier Proteins, Case-Control Studies, Colitis, Ulcerative, Crohn Disease, Genetic Predisposition to Disease, Genetic Variation, Humans, Immunoglobulins, Inflammatory Bowel Diseases, Intracellular Signaling Peptides and Proteins, Linkage Disequilibrium, Nod2 Signaling Adaptor Protein, Pedigree, Polymorphism, Single Nucleotide",

author = "K King and A Moody and Fisher, {S A} and Mirza, {M M} and Cuthbert, {A P} and J Hampe and A Sutherland-Craggs and J Sanderson and MacPherson, {A J} and A Forbes and J Mansfield and S Schreiber and Lewis, {C M} and Mathew, {C G}",

year = "2003",

month = jun,

doi = "10.1046/j.1365-2370.2003.00387.x",

language = "English",

volume = "30",

pages = "187--190",

journal = "European Journal of Immunogenetics",

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King, K, Moody, A, Fisher, SA, Mirza, MM, Cuthbert, AP, Hampe, J, Sutherland-Craggs, A, Sanderson, J, MacPherson, AJ, Forbes, A, Mansfield, J, Schreiber, S, Lewis, CM & Mathew, CG 2003, 'Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease', European Journal of Immunogenetics, vol. 30, no. 3, pp. 187-190. https://doi.org/10.1046/j.1365-2370.2003.00387.x

TY - JOUR

T1 - Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease

AU - King, K

AU - Moody, A

AU - Fisher, S A

AU - Mirza, M M

AU - Cuthbert, A P

AU - Hampe, J

AU - Sutherland-Craggs, A

AU - Sanderson, J

AU - MacPherson, A J

AU - Forbes, A

AU - Mansfield, J

AU - Schreiber, S

AU - Lewis, C M

AU - Mathew, C G

PY - 2003/6

Y1 - 2003/6

N2 - The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of IGSF6 for single nucleotide polymorphisms (SNPs) detected four novel SNPs, and validated three of six SNPs listed in the international SNP database (dbSNP). The seven SNPs in IGSF6 formed five distinct linkage disequilibrium groups. There was no evidence for association of the common SNPs with disease in a large cohort of patients with IBD. The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders.

AB - The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of IGSF6 for single nucleotide polymorphisms (SNPs) detected four novel SNPs, and validated three of six SNPs listed in the international SNP database (dbSNP). The seven SNPs in IGSF6 formed five distinct linkage disequilibrium groups. There was no evidence for association of the common SNPs with disease in a large cohort of patients with IBD. The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders.

KW - Antigens, CD8

KW - Carrier Proteins

KW - Case-Control Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Humans

KW - Immunoglobulins

KW - Inflammatory Bowel Diseases

KW - Intracellular Signaling Peptides and Proteins

KW - Linkage Disequilibrium

KW - Nod2 Signaling Adaptor Protein

KW - Pedigree

KW - Polymorphism, Single Nucleotide

U2 - 10.1046/j.1365-2370.2003.00387.x

DO - 10.1046/j.1365-2370.2003.00387.x

M3 - Article

C2 - 12786995

VL - 30

SP - 187

EP - 190

JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

SN - 0960-7420

IS - 3

ER -