Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Alastair Forbes, Wellcome Trust Case Control Consortium

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7462 Citations (Scopus)

Abstract

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study (using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined approximately 2,000 individuals for each of 7 major diseases and a shared set of approximately 3,000 controls. Case-control comparisons identified 24 independent association signals at P
Original languageEnglish
Pages (from-to)661-78
Number of pages18
JournalNature
Volume447
Issue number7145
DOIs
Publication statusPublished - 7 Jun 2007

Keywords

  • Arthritis, Rheumatoid
  • Bipolar Disorder
  • Case-Control Studies
  • Chromosomes, Human
  • Coronary Artery Disease
  • Crohn Disease
  • Diabetes Mellitus
  • Gene Frequency
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genetics, Population
  • Genome, Human
  • Geography
  • Great Britain
  • Humans
  • Hypertension

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