Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

Marijana Radonjic, Jorn R de Haan, Marjan J van Erk, Ko Willems van Dijk, Sjoerd A A van den Berg, Philip J de Groot, Michael Müller, Ben van Ommen

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.
Original languageEnglish
Article numbere6646
JournalPLoS One
Volume4
Issue number8
DOIs
Publication statusPublished - 14 Aug 2009

Keywords

  • Adaptation, Physiological
  • Animals
  • Blood Proteins
  • Dietary Fats
  • Fatty Liver
  • Genome
  • Liver
  • Male
  • Mice
  • Mice, Transgenic
  • RNA, Messenger
  • Transcription, Genetic
  • Triglycerides

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