Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

Marijana Radonjic; Jorn R. de Haan; Marjan J. van Erk; Ko Willems van Dijk; Sjoerd A. A. van den Berg; Philip J. de Groot; Michael Müller; Ben van Ommen

doi:10.1371/journal.pone.0006646

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

Marijana Radonjic
, Jorn R. de Haan
, Marjan J. van Erk
, Ko Willems van Dijk
, Sjoerd A. A. van den Berg
, Philip J. de Groot
, Michael Müller
, Ben van Ommen

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.

Original language	English
Article number	e6646
Journal	PLoS One
Volume	4
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0006646
Publication status	Published - 14 Aug 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adaptation, Physiological
Animals
Blood Proteins
Dietary Fats
Fatty Liver
Genome
Liver
Male
Mice
Mice, Transgenic
RNA, Messenger
Transcription, Genetic
Triglycerides

Access to Document

10.1371/journal.pone.0006646Licence: CC BY

Cite this

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title = "Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program",

abstract = "Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.",

keywords = "Adaptation, Physiological, Animals, Blood Proteins, Dietary Fats, Fatty Liver, Genome, Liver, Male, Mice, Mice, Transgenic, RNA, Messenger, Transcription, Genetic, Triglycerides",

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T1 - Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

AU - Radonjic, Marijana

AU - de Haan, Jorn R.

AU - van Erk, Marjan J.

AU - van Dijk, Ko Willems

AU - van den Berg, Sjoerd A. A.

AU - de Groot, Philip J.

AU - Müller, Michael

AU - van Ommen, Ben

N1 - © 2009 Radonjic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2009/8/14

Y1 - 2009/8/14

N2 - Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.

AB - Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.

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KW - Animals

KW - Blood Proteins

KW - Dietary Fats

KW - Fatty Liver

KW - Genome

KW - Liver

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - RNA, Messenger

KW - Transcription, Genetic

KW - Triglycerides

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