Getting the payload in place - Unravelling the complexities of making a bacterial microcompartment

Michael D. Paxhia; Mingzhi Liang; Martin J. Warren

doi:10.1128/jb.00127-22

Getting the payload in place - Unravelling the complexities of making a bacterial microcompartment

Michael D. Paxhia, Mingzhi Liang, Martin J. Warren

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Bacterial microcompartments (BMCs) are complex macromolecular assemblies composed of any outer protein shell that encases a specific metabolic pathway cargo. Recent research is now starting to unravel some of the processes that are involved in directing the enzyme cargo to the inside of the BMC. In particular, an article in this issue of J Bacteriol by N. W. Kennedy, C. E. Mills, C. H. Abrahamson, A. Archer, et al. (J Bacteriol 204:e00576-21, 2022, https://doi.org/10.1128/jb.00576-21) highlights the role played by the shell protein PduB in coordinating this internalization process.

Original language	English
Article number	e0012722
Journal	Journal of Bacteriology
Volume	204
Issue number	9
Early online date	24 Aug 2022
DOIs	https://doi.org/10.1128/jb.00127-22
Publication status	Published - 20 Sep 2022

Keywords

bacterial microcompartment
cargo
enzyme
pathway

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10.1128/jb.00127-22

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title = "Getting the payload in place - Unravelling the complexities of making a bacterial microcompartment",

abstract = "Bacterial microcompartments (BMCs) are complex macromolecular assemblies composed of any outer protein shell that encases a specific metabolic pathway cargo. Recent research is now starting to unravel some of the processes that are involved in directing the enzyme cargo to the inside of the BMC. In particular, an article in this issue of J Bacteriol by N. W. Kennedy, C. E. Mills, C. H. Abrahamson, A. Archer, et al. (J Bacteriol 204:e00576-21, 2022, https://doi.org/10.1128/jb.00576-21) highlights the role played by the shell protein PduB in coordinating this internalization process.",

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note = "Funding Information: We thank Shanghai Jiao Tong University, Chinese Academy of Sciences, The Chinese National Human Genome Center at Shanghai, the Science & Technology Commission of Shanghai Municipality, the National Natural Science Foundation of China, the Unilever Co. Ltd. and the National 973 projects for generous financial support.",

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AU - Liang, Mingzhi

AU - Warren, Martin J.

N1 - Funding Information: We thank Shanghai Jiao Tong University, Chinese Academy of Sciences, The Chinese National Human Genome Center at Shanghai, the Science & Technology Commission of Shanghai Municipality, the National Natural Science Foundation of China, the Unilever Co. Ltd. and the National 973 projects for generous financial support.

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N2 - Bacterial microcompartments (BMCs) are complex macromolecular assemblies composed of any outer protein shell that encases a specific metabolic pathway cargo. Recent research is now starting to unravel some of the processes that are involved in directing the enzyme cargo to the inside of the BMC. In particular, an article in this issue of J Bacteriol by N. W. Kennedy, C. E. Mills, C. H. Abrahamson, A. Archer, et al. (J Bacteriol 204:e00576-21, 2022, https://doi.org/10.1128/jb.00576-21) highlights the role played by the shell protein PduB in coordinating this internalization process.

AB - Bacterial microcompartments (BMCs) are complex macromolecular assemblies composed of any outer protein shell that encases a specific metabolic pathway cargo. Recent research is now starting to unravel some of the processes that are involved in directing the enzyme cargo to the inside of the BMC. In particular, an article in this issue of J Bacteriol by N. W. Kennedy, C. E. Mills, C. H. Abrahamson, A. Archer, et al. (J Bacteriol 204:e00576-21, 2022, https://doi.org/10.1128/jb.00576-21) highlights the role played by the shell protein PduB in coordinating this internalization process.

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KW - cargo

KW - enzyme

KW - pathway

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Getting the payload in place - Unravelling the complexities of making a bacterial microcompartment

Abstract

Keywords

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