Global prevalence of depression in HIV/AIDS: A systematic review and meta-analysis

Sepide Rezaei, Saba Ahmadi, Jeiran Rahmati, Hossein Hosseinifard, Afsaneh Dehnad, Aidin Aryankhesal, Hosein Shabaninejad, Shabnam Ghasemyani, Samira Alihosseini, Nicola Luigi Bragazzi, Samira Raoofi, Zahra Mansour Kiaee, Ahmad Ghashghaee

Research output: Contribution to journalReview articlepeer-review

94 Citations (Scopus)


Introduction: The incidence of some fatal diseases, including HIV/AIDS, accompanied by depression has become a significant concern in developed, developing and underdeveloped countries. A great deal of time and money are spent on controlling and reducing the complications of this infection across the world. Accordingly, the main purpose of this study was to clarify the global prevalence rate of depression in patients living with HIV/AIDS via a systematic review and meta-analysis. Methodology: All articles in English, published between 2000 and 2018, were systematically searched from the original databases of Web of Science, PubMed, Scopus, Cochrane Library, Google Scholar and Embase. As a result, a total of 118 articles were identified. Results: The total sample size in these articles was 51143 people, and the number of patients suffering from moderate and severe levels of depression was 14 942. The results of the analysis based on the random-effects (DerSimonian and Laird) model revealed that the prevalence rate of depression in patients with HIV/AIDS was 31% (95% CI 28% to 34%), with a 98% heterogeneity index which was reported significant. Meanwhile, the highest prevalence rate of depression based on continent was in South America at 44% (95% CI 35% to 53%) and the lowest rate was in Europe at 22% (95% CI 17% to 27%). Conclusion: In general, there was a higher prevalence rate of depression in developing and underdeveloped countries than in developed countries, which could be attributed to the advancement of science and the possibilities for early diagnosis of this syndrome. Trial registration number: CRD42019119137.

Original languageEnglish
Pages (from-to)404-412
Number of pages9
JournalBMJ Supportive and Palliative Care
Issue number4
Early online date19 Sep 2019
Publication statusPublished - 3 Dec 2019


  • depression
  • global
  • HIV
  • prevalence
  • systematic review & meta-analysis

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