Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression

P A Kitchen; A J Fitzgerald; R A Goodlad; N F Barley; M A Ghatei; S Legon; S R Bloom; A Price; J R Walters; A Forbes

doi:10.1152/ajpgi.2000.278.3.G425#

Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression

P A Kitchen, A J Fitzgerald, R A Goodlad, N F Barley, M A Ghatei, S Legon, S R Bloom, A Price, J R Walters, A Forbes

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

To determine the effect of glucagon-like peptide-2 (GLP-2) on sucrase-isomaltase and caudal-related homeobox protein-2 (Cdx-2) gene expression, male Wistar rats were divided into total parenteral nutrition (TPN)-fed and GLP-2-treated, TPN-fed groups. TPN was given via a jugular line, inserted under anesthesia, for 7 days. The treatment group received 40 microg/day of GLP-2 intravenously with the TPN diet. The small intestine and colon were weighed and measured. Tissue was obtained from the jejunum, terminal ileum, and midcolon. RNA analysis, morphometry, and microdissection were performed. The weight of the small intestine of GLP-2-treated rats was greater than that of TPN-fed rats (P

Original language	English
Pages (from-to)	G425-8
Journal	AJP: Gastrointestinal and Liver Physiology
Volume	278
Issue number	3
DOIs	https://doi.org/10.1152/ajpgi.2000.278.3.G425#
Publication status	Published - Mar 2000

Keywords

Animals
Colon
Gene Expression
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Homeodomain Proteins
Ileum
Jejunum
Male
Parenteral Nutrition, Total
Peptides
Rats
Rats, Wistar
Sucrase-Isomaltase Complex
Trans-Activators

Access to Document

10.1152/ajpgi.2000.278.3.G425#

Cite this

Kitchen, P. A., Fitzgerald, A. J., Goodlad, R. A., Barley, N. F., Ghatei, M. A., Legon, S., Bloom, S. R., Price, A., Walters, J. R., & Forbes, A. (2000). Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. AJP: Gastrointestinal and Liver Physiology, 278(3), G425-8. https://doi.org/10.1152/ajpgi.2000.278.3.G425#

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abstract = "To determine the effect of glucagon-like peptide-2 (GLP-2) on sucrase-isomaltase and caudal-related homeobox protein-2 (Cdx-2) gene expression, male Wistar rats were divided into total parenteral nutrition (TPN)-fed and GLP-2-treated, TPN-fed groups. TPN was given via a jugular line, inserted under anesthesia, for 7 days. The treatment group received 40 microg/day of GLP-2 intravenously with the TPN diet. The small intestine and colon were weighed and measured. Tissue was obtained from the jejunum, terminal ileum, and midcolon. RNA analysis, morphometry, and microdissection were performed. The weight of the small intestine of GLP-2-treated rats was greater than that of TPN-fed rats (P ",

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Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. / Kitchen, P A; Fitzgerald, A J; Goodlad, R A; Barley, N F; Ghatei, M A; Legon, S; Bloom, S R; Price, A; Walters, J R; Forbes, A.

In: AJP: Gastrointestinal and Liver Physiology, Vol. 278, No. 3, 03.2000, p. G425-8.

Research output: Contribution to journal › Article › peer-review

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