Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Neil J Howell; Houman Ashrafian; Nigel E Drury; Aaron M Ranasinghe; Hussain Contractor; Henrik Isackson; Melanie Calvert; Lynne K Williams; Nick Freemantle; David W Quinn; David Green; Michael Frenneaux; Robert S Bonser; Jorge G Mascaro; Timothy R Graham; Stephen J Rooney; Ian C Wilson; Domenico Pagano

doi:10.1161/CIRCULATIONAHA.110.945170

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Neil J Howell, Houman Ashrafian, Nigel E Drury, Aaron M Ranasinghe, Hussain Contractor, Henrik Isackson, Melanie Calvert, Lynne K Williams, Nick Freemantle, David W Quinn, David Green, Michael Frenneaux, Robert S Bonser, Jorge G Mascaro, Timothy R Graham, Stephen J Rooney, Ian C Wilson, Domenico Pagano

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.

Original language	English
Pages (from-to)	170-7
Number of pages	8
Journal	Circulation
Volume	123
Issue number	2
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.945170
Publication status	Published - 18 Jan 2011

Keywords

AMP-Activated Protein Kinases
Acetylglucosamine
Aged
Aortic Valve
Aortic Valve Stenosis
Cardiac Output, Low
Double-Blind Method
Female
Glucose
Heart Valve Prosthesis
Humans
Hypertrophy, Left Ventricular
Incidence
Insulin
Male
Middle Aged
Phosphatidylinositol 3-Kinases
Potassium
Proto-Oncogene Proteins c-akt
Risk Factors
Treatment Outcome

Access to Document

10.1161/CIRCULATIONAHA.110.945170

Cite this

Howell, N. J., Ashrafian, H., Drury, N. E., Ranasinghe, A. M., Contractor, H., Isackson, H., Calvert, M., Williams, L. K., Freemantle, N., Quinn, D. W., Green, D., Frenneaux, M., Bonser, R. S., Mascaro, J. G., Graham, T. R., Rooney, S. J., Wilson, I. C., & Pagano, D. (2011). Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation, 123(2), 170-7. https://doi.org/10.1161/CIRCULATIONAHA.110.945170

Howell, Neil J ; Ashrafian, Houman ; Drury, Nigel E ; Ranasinghe, Aaron M ; Contractor, Hussain ; Isackson, Henrik ; Calvert, Melanie ; Williams, Lynne K ; Freemantle, Nick ; Quinn, David W ; Green, David ; Frenneaux, Michael ; Bonser, Robert S ; Mascaro, Jorge G ; Graham, Timothy R ; Rooney, Stephen J ; Wilson, Ian C ; Pagano, Domenico. / Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy : results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. In: Circulation. 2011 ; Vol. 123, No. 2. pp. 170-7.

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abstract = "Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.",

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author = "Howell, {Neil J} and Houman Ashrafian and Drury, {Nigel E} and Ranasinghe, {Aaron M} and Hussain Contractor and Henrik Isackson and Melanie Calvert and Williams, {Lynne K} and Nick Freemantle and Quinn, {David W} and David Green and Michael Frenneaux and Bonser, {Robert S} and Mascaro, {Jorge G} and Graham, {Timothy R} and Rooney, {Stephen J} and Wilson, {Ian C} and Domenico Pagano",

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doi = "10.1161/CIRCULATIONAHA.110.945170",

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Howell, NJ, Ashrafian, H, Drury, NE, Ranasinghe, AM, Contractor, H, Isackson, H, Calvert, M, Williams, LK, Freemantle, N, Quinn, DW, Green, D, Frenneaux, M, Bonser, RS, Mascaro, JG, Graham, TR, Rooney, SJ, Wilson, IC & Pagano, D 2011, 'Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial', Circulation, vol. 123, no. 2, pp. 170-7. https://doi.org/10.1161/CIRCULATIONAHA.110.945170

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy : results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. / Howell, Neil J; Ashrafian, Houman; Drury, Nigel E; Ranasinghe, Aaron M; Contractor, Hussain; Isackson, Henrik; Calvert, Melanie; Williams, Lynne K; Freemantle, Nick; Quinn, David W; Green, David; Frenneaux, Michael; Bonser, Robert S; Mascaro, Jorge G; Graham, Timothy R; Rooney, Stephen J; Wilson, Ian C; Pagano, Domenico.

In: Circulation, Vol. 123, No. 2, 18.01.2011, p. 170-7.

Research output: Contribution to journal › Article › peer-review

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T2 - results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

AU - Howell, Neil J

AU - Ashrafian, Houman

AU - Drury, Nigel E

AU - Ranasinghe, Aaron M

AU - Contractor, Hussain

AU - Isackson, Henrik

AU - Calvert, Melanie

AU - Williams, Lynne K

AU - Freemantle, Nick

AU - Quinn, David W

AU - Green, David

AU - Frenneaux, Michael

AU - Bonser, Robert S

AU - Mascaro, Jorge G

AU - Graham, Timothy R

AU - Rooney, Stephen J

AU - Wilson, Ian C

AU - Pagano, Domenico

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AB - Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.

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KW - Female

KW - Glucose

KW - Heart Valve Prosthesis

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Incidence

KW - Insulin

KW - Male

KW - Middle Aged

KW - Phosphatidylinositol 3-Kinases

KW - Potassium

KW - Proto-Oncogene Proteins c-akt

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1161/CIRCULATIONAHA.110.945170

DO - 10.1161/CIRCULATIONAHA.110.945170

M3 - Article

C2 - 21200004

VL - 123

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EP - 177

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 2

ER -

Howell NJ, Ashrafian H, Drury NE, Ranasinghe AM, Contractor H, Isackson H et al. Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation. 2011 Jan 18;123(2):170-7. https://doi.org/10.1161/CIRCULATIONAHA.110.945170