Glyconanoparticles for colorimetric bioassays

MJ Marin, Claire Schofield, Robert Field, David Russell

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
4 Downloads (Pure)

Abstract

Carbohydrate molecules are involved in many of the cellular processes that are important for life. By combining the specific analyte targeting of carbohydrates with the multivalent structure and change of solution colour as a consequence of plasmonic interactions with the aggregation of metal nanoparticles, glyconanoparticles have been used extensively for the development of bioanalytical assays. The noble metals used to create the nanocore, the methodologies used to assemble the carbohydrates on the nanoparticle surface, the carbohydrate chosen for each specific target, the length of the tether that separates the carbohydrate from the nanocore and the density of carbohydrates on the surface all impact on the structural formation of metal based glyconanoparticles. This tutorial review highlights these key components, which directly impact on the selectivity and sensitivity of the developed bioassay, for the colorimetric detection of lectins, toxins and viruses.
Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalAnalyst
Volume140
Early online date3 Oct 2014
DOIs
Publication statusPublished - 2015

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