Gold(III) complexes for antitumor applications: An overview

Benoît Bertrand, Morwen R. M. Williams, Manfred Bochmann

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)
29 Downloads (Pure)


Gold(III) complexes have emerged as a versatile and effective class of metal‐based anticancer agents. The development of various types of ligands capable of stabilizing the AuIII cation and preventing its reduction under physiological conditions, such as chelating nitrogen‐donors, dithiocarbamates and C^N cyclometalled ligands, has opened the way for the exploration of their potential intracellular targets and action mechanisms. At the same time, the bioconjugation of AuIII complexes has emerged as a promising strategy for improving the selectivity of this class of compounds for cancer cells over healthy tissues, and recent developments have shown that combining gold complexes with molecular structures that are specifically recognized by the cell can exploit the cell's own transport mechanisms to improve selective metal uptake.
Original languageEnglish
Pages (from-to)11840-11851
Number of pages12
JournalChemistry - A European Journal
Issue number46
Early online date25 Mar 2018
Publication statusPublished - 14 Aug 2018


  • antitumor agents
  • bioinorganic chemistry
  • cancer gold
  • pincer ligands

Cite this