Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy

Paul W X Foley, Berthold Stegemann, Kelvin Ng, Sud Ramachandran, Anthony Proudler, Michael P Frenneaux, Leong L Ng, Francisco Leyva

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44 Citations (Scopus)

Abstract

The aim of this study was to determine whether growth differentiation factor-15 (GDF-15) predicts mortality and morbidity after cardiac resynchronization therapy (CRT). Growth differentiation factor-15, a transforming growth factor-beta-related cytokine which is up-regulated in cardiomyocytes via multiple stress pathways, predicts mortality in patients with heart failure treated pharmacologically.
Original languageEnglish
Pages (from-to)2749-2757
Number of pages9
JournalEuropean Heart Journal
Volume30
Issue number22
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Aged
  • Area Under Curve
  • Biological Markers
  • Cardiac Pacing, Artificial
  • Defibrillators, Implantable
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Growth Differentiation Factor 15
  • Heart Failure
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Risk Factors
  • Survival Analysis

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