Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients

H. D. White, A. M. Ahmad, B. H. Durham, A. Patwala, P. Whittingham, W. D. Fraser, J. P. Vora

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Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated.
Original languageEnglish
Pages (from-to)3371-3380
Number of pages10
JournalJournal of Clinical Endocrinology & Metabolism
Issue number6
Publication statusPublished - Jun 2005

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