Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients

H. D. White; A. M. Ahmad; B. H. Durham; A. Patwala; P. Whittingham; W. D. Fraser; J. P. Vora

doi:10.1210/jc.2004-1650

Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients

H. D. White, A. M. Ahmad, B. H. Durham, A. Patwala, P. Whittingham, W. D. Fraser, J. P. Vora

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated.

Original language	English
Pages (from-to)	3371-3380
Number of pages	10
Journal	Journal of Clinical Endocrinology & Metabolism
Volume	90
Issue number	6
DOIs	https://doi.org/10.1210/jc.2004-1650
Publication status	Published - Jun 2005

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10.1210/jc.2004-1650

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White, H. D., Ahmad, A. M., Durham, B. H., Patwala, A., Whittingham, P., Fraser, W. D., & Vora, J. P. (2005). Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. Journal of Clinical Endocrinology & Metabolism, 90(6), 3371-3380. https://doi.org/10.1210/jc.2004-1650

White, H. D. ; Ahmad, A. M. ; Durham, B. H. ; Patwala, A. ; Whittingham, P. ; Fraser, W. D. ; Vora, J. P. / Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. In: Journal of Clinical Endocrinology & Metabolism. 2005 ; Vol. 90, No. 6. pp. 3371-3380.

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abstract = "Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated.",

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White, HD, Ahmad, AM, Durham, BH, Patwala, A, Whittingham, P, Fraser, WD & Vora, JP 2005, 'Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients', Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 6, pp. 3371-3380. https://doi.org/10.1210/jc.2004-1650

Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. / White, H. D.; Ahmad, A. M.; Durham, B. H.; Patwala, A.; Whittingham, P.; Fraser, W. D.; Vora, J. P.

In: Journal of Clinical Endocrinology & Metabolism, Vol. 90, No. 6, 06.2005, p. 3371-3380.

Research output: Contribution to journal › Article

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AB - Alterations in PTH circadian rhythm and PTH target-organ sensitivity exist in adult GH-deficient (AGHD) patients and may underlie the pathogenesis of AGHD-related osteoporosis. GH replacement (GHR) results in increased bone mineral density, but its benefit in AGHD patients over 60 yr old has been debated.

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