TY - JOUR
T1 - Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment
AU - Xia, Yin-Yin
AU - de Seymour, Jamie V.
AU - Yang, Xiao-Jia
AU - Zhou, Lin-Wei
AU - Liu, Yue
AU - Yang, Yang
AU - Beck, Kathryn L.
AU - Conlon, Cathryn A.
AU - Mansell, Toby
AU - Novakovic, Boris
AU - Saffery, Richard
AU - Han, Ting-Li
AU - Zhang, Hua
AU - Baker, Philip N.
N1 - Data availability: The data that support the findings of this study are available on request from the corresponding author on reasonable request.
Funding information: This work was supported by the National Natural Science Foundation of China (No. 81871185, 81971406, 82271715), The 111 Project (Yuwaizhuan (2016)32), Chongqing Science and Technology Commission (CSTC2021JCYJ-MSXMX0213, CSTB2022NSCQ-MSX1679, CSTB2022NSCQ-MSX1680), Chongqing Municipal Education Commission (KJZD-K202100407), Chongqing Health Commission and Chongqing Science & Technology Commission (2021MSXM121, 2020MSXM101), Smart Medicine Research Project of Chongqing Medical University (No. ZHYX202103), Senior Medical Talents Program of Chongqing for Young and Middle-aged [2022] 15, Kuanren Talents Programs of Second Affiliated Hospital of Chongqing Medical University, and a joint Health Research Council New Zealand–National Science Foundation of China Biomedical Research Fund (19/804).
PY - 2023/10
Y1 - 2023/10
N2 - Background & aims: Exposure to a range of elements, air pollution, and specific dietary components in pregnancy has variously been associated with gestational diabetes mellitus (GDM) risk or infant neurodevelopmental problems. We measured a range of pregnancy exposures in maternal hair and/or infant cord serum and tested their relationship to GDM and infant neurodevelopment. Methods: A total of 843 pregnant women (GDM = 224, Non-GDM = 619) were selected from the Complex Lipids in Mothers and Babies cohort study. Forty-eight elements in hair and cord serum were quantified using inductively coupled plasma-mass spectrometry analysis. Binary logistic regression was used to estimate the associations between hair element concentrations and GDM risk, while multiple linear regression was performed to analyze the relationship between hair/cord serum elements and air pollutants, diet exposures, and Bayley Scales of infant neurodevelopment at 12 months of age. Results: After adjusting for maternal age, BMI, and primiparity, we observed that fourteen elements in maternal hair were associated with a significantly increased risk of GDM, particularly Ta (OR = 9.49, 95% CI: 6.71, 13.42), Re (OR = 5.21, 95% CI: 3.84, 7.07), and Se (OR = 5.37, 95% CI: 3.48, 8.28). In the adjusted linear regression model, three elements (Rb, Er, and Tm) in maternal hair and infant cord serum were negatively associated with Mental Development Index scores. For dietary exposures, elements were positively associated with noodles (Nb), sweetened beverages (Rb), poultry (Cs), oils and condiments (Ca), and other seafood (Gd). In addition, air pollutants PM2.5 (LUR) and PM10 were negatively associated with Ta and Re in maternal hair. Conclusions: Our findings highlight the potential influence of maternal element exposure on GDM risk and infant neurodevelopment. We identified links between levels of these elements in both maternal hair and infant cord serum related to air pollutants and dietary factors.
AB - Background & aims: Exposure to a range of elements, air pollution, and specific dietary components in pregnancy has variously been associated with gestational diabetes mellitus (GDM) risk or infant neurodevelopmental problems. We measured a range of pregnancy exposures in maternal hair and/or infant cord serum and tested their relationship to GDM and infant neurodevelopment. Methods: A total of 843 pregnant women (GDM = 224, Non-GDM = 619) were selected from the Complex Lipids in Mothers and Babies cohort study. Forty-eight elements in hair and cord serum were quantified using inductively coupled plasma-mass spectrometry analysis. Binary logistic regression was used to estimate the associations between hair element concentrations and GDM risk, while multiple linear regression was performed to analyze the relationship between hair/cord serum elements and air pollutants, diet exposures, and Bayley Scales of infant neurodevelopment at 12 months of age. Results: After adjusting for maternal age, BMI, and primiparity, we observed that fourteen elements in maternal hair were associated with a significantly increased risk of GDM, particularly Ta (OR = 9.49, 95% CI: 6.71, 13.42), Re (OR = 5.21, 95% CI: 3.84, 7.07), and Se (OR = 5.37, 95% CI: 3.48, 8.28). In the adjusted linear regression model, three elements (Rb, Er, and Tm) in maternal hair and infant cord serum were negatively associated with Mental Development Index scores. For dietary exposures, elements were positively associated with noodles (Nb), sweetened beverages (Rb), poultry (Cs), oils and condiments (Ca), and other seafood (Gd). In addition, air pollutants PM2.5 (LUR) and PM10 were negatively associated with Ta and Re in maternal hair. Conclusions: Our findings highlight the potential influence of maternal element exposure on GDM risk and infant neurodevelopment. We identified links between levels of these elements in both maternal hair and infant cord serum related to air pollutants and dietary factors.
KW - Air pollutant exposures
KW - Gestational diabetes mellitus
KW - Hair elements
KW - Inductively coupled plasma-mass spectrometry
KW - Infant neurodevelopment
KW - Maternal diet
UR - http://www.scopus.com/inward/record.url?scp=85168736635&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2023.08.009
DO - 10.1016/j.clnu.2023.08.009
M3 - Article
C2 - 37625317
AN - SCOPUS:85168736635
SN - 0261-5614
VL - 42
SP - 1875
EP - 1888
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 10
ER -
