Health-related quality of life following TAVI or cardiac surgery in patients at intermediate and low risk: a systematic review and meta-analysis

Ahmed R. Gonnah, Mohamed Abdelwahab, Rebecca Taylor, Aser Labib, Omar Masoud, Maciej Debski, Hesham Kamal Abdelaziz, David Hesketh Roberts

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Abstract

Recent randomised trials have shown that clinical outcomes with transcatheter aortic valve implantation (TAVI) are non-inferior to surgical aortic valve replacement (SAVR) in patients with symptomatic aortic stenosis at intermediate to low risk. Health-related quality of life (HrQoL) outcomes in these patient groups remain uncertain. A systematic search of the literature was conducted that included nine trials and 11,295 patients. Kansas City Cardiomyopathy Questionnaire (KCCQ), a heart-failure-specific measure and EuroQol-5D (EQ-5D) (a generic health status tool) changes were the primary outcomes. New York Heart Association (NYHA) classification was the secondary outcome. Improvement in KCCQ scores was greater with TAVI (mean difference (MD)=13.56, 95% confidence interval (CI) 11.67–15.46, p<0.001) at 1 month, as was the improvement in EQ-5D (MD=0.07, 95% CI 0.05–0.08, p<0.001). There was no difference in KCCQ (MD=1.05, 95% CI −0.11 to 2.21, p=0.08) or EQ-5D (MD=–0.01, 95% CI −0.03 to 0.01), p=0.37) at 12 months. NYHA functional class 3/4 was lower in patients undergoing TAVI at 1 month (MD=0.51, 95% CI 0.34–0.78, p=0.002), but there was no difference at 12 months (MD=1.10; 95% CI 0.87–1.38, p=0.43). Overall, TAVI offers early benefit in HRQoL outcomes compared with SAVR, but they are equivalent at 12 months.
Original languageEnglish
Pages (from-to)594-605
Number of pages12
JournalClinical Medicine
Volume23
Issue number6
DOIs
Publication statusPublished - Nov 2023

Keywords

  • EQ-5D
  • KCCQ
  • NYHA
  • SAVR
  • TAVI
  • aortic stenosis

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