Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis

Michael Walsh, Chetan Mukhtyar, Alfred Mahr, Karen Herlyn, Raashid Luqmani, Peter A Merkel, David R W Jayne

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


OBJECTIVE: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can present with a broad spectrum of signs and symptoms. The relative effects of different manifestations on health-related quality of life (HRQOL) are unknown.

METHODS: We conducted an individual patient data meta-analysis of baseline Short Form 36 (SF-36) scores from 4 randomized controlled trials of patients with newly diagnosed AAV. We determined the associations between organ manifestations at trial entry and the SF-36 physical composite score (PCS) and mental composite score (MCS) using mixed-effects models adjusted for demographic factors. Associations with each of the 8 domains of the SF-36 were further explored using multivariate multiple regression.

RESULTS: SF-36 data were available from 346 patients. Older age (-0.11 points/year [95% confidence interval (95% CI) -0.21, -0.012]; P = 0.029) and neurologic involvement (-5.84 points; P < 0.001) at baseline were associated with lower PCS. Physical functioning scores were the most affected and older age scores (-0.25 points/year [95% CI -0.38, -0.11]; P < 0.001) and neurologic involvement (-8.48 points [95% CI -12.90, -4.06]; P < 0.001) had the largest effects. The MCS was negatively affected only by chest involvement (P = 0.027), but this effect was not exerted in any particular domain.

CONCLUSION: In patients with newly diagnosed AAV, HRQOL is complex and incompletely explained by their organ system manifestations.

Original languageEnglish
Pages (from-to)1055-1061
Number of pages7
JournalArthritis Care & Research
Issue number7
Early online date30 Mar 2011
Publication statusPublished - Jul 2011


  • Adult
  • Age Factors
  • Aged
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis
  • Antibodies, Antineutrophil Cytoplasmic
  • Female
  • Health Status
  • Humans
  • Male
  • Middle Aged
  • Quality of Life/psychology
  • Self Report
  • Surveys and Questionnaires

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