Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group

Joseph G Pressey; James R Anderson; David K Crossman; James C Lynch; Frederic G Barr

doi:10.1002/pbc.23174

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group

Joseph G Pressey, James R Anderson, David K Crossman, James C Lynch, Frederic G Barr

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Aberrant activation of the hedgehog (Hh) signaling pathway is implicated widely in both pediatric and adult malignancies. Inactivation of the Hh regulator PTCH is responsible for the Gorlin cancer predisposition syndrome. The spectrum of tumors found in Gorlin Syndrome includes basal cell carcinoma, medulloblastoma, and rarely, rhabdomyosarcoma (RMS). A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors.

Original language	English
Pages (from-to)	930-8
Number of pages	9
Journal	Pediatric Blood & Cancer
Volume	57
Issue number	6
DOIs	https://doi.org/10.1002/pbc.23174
Publication status	Published - 1 Dec 2011

Keywords

Cell Line, Tumor
Hedgehog Proteins
Humans
Oligonucleotide Array Sequence Analysis
RNA, Messenger
Receptors, Cell Surface
Rhabdomyosarcoma
Sarcoma
Signal Transduction
Transcription Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/pbc.23174

Cite this

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title = "Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group",

abstract = "Aberrant activation of the hedgehog (Hh) signaling pathway is implicated widely in both pediatric and adult malignancies. Inactivation of the Hh regulator PTCH is responsible for the Gorlin cancer predisposition syndrome. The spectrum of tumors found in Gorlin Syndrome includes basal cell carcinoma, medulloblastoma, and rarely, rhabdomyosarcoma (RMS). A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors.",

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AU - Anderson, James R

AU - Crossman, David K

AU - Lynch, James C

AU - Barr, Frederic G

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AB - Aberrant activation of the hedgehog (Hh) signaling pathway is implicated widely in both pediatric and adult malignancies. Inactivation of the Hh regulator PTCH is responsible for the Gorlin cancer predisposition syndrome. The spectrum of tumors found in Gorlin Syndrome includes basal cell carcinoma, medulloblastoma, and rarely, rhabdomyosarcoma (RMS). A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors.

KW - Cell Line, Tumor

KW - Hedgehog Proteins

KW - Humans

KW - Oligonucleotide Array Sequence Analysis

KW - RNA, Messenger

KW - Receptors, Cell Surface

KW - Rhabdomyosarcoma

KW - Sarcoma

KW - Signal Transduction

KW - Transcription Factors

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JO - Pediatric Blood & Cancer

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