Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

Francisco J. Cubero; Gang Zhao; Yulia A. Nevzorova; Maximilian Hatting; Malika Al Masaoudi; Julien Verdier; Jin Peng; Frederik M. Schaefer; Nadine Hermanns; Mark V. Boekschoten; Christoph Grouls; Nikolaus Gassler; Fabian Kiessling; Michael Muller; Roger J. Davis; Christian Liedtke; Christian Trautwein

doi:10.1016/j.jhep.2014.08.029

Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

Francisco J. Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, Malika Al Masaoudi, Julien Verdier, Jin Peng, Frederik M. Schaefer, Nadine Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gassler, Fabian Kiessling, Michael Muller, Roger J. Davis, Christian Liedtke, Christian Trautwein

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury.

Original language	English
Pages (from-to)	140-149
Number of pages	10
Journal	Journal of Hepatology
Volume	62
Issue number	1
Early online date	1 Aug 2014
DOIs	https://doi.org/10.1016/j.jhep.2014.08.029
Publication status	Published - Jan 2015

Keywords

Jnk1
Jnk2
Necrosis
Apoptosis
IKKγ/NEMO
HCC

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10.1016/j.jhep.2014.08.029

Michael Muller
- Michael.Mulleruea.acuk
- Norwich Medical School - Emeritus Professor, Professor of Nutrigenomics and Systems Nutrition
- Norwich Institute for Healthy Aging - Member
- Metabolic Health - Member
- Gastroenterology and Gut Biology - Member
- Nutrition and Preventive Medicine - Member
Person: Honorary, Other related - academic, Research Group Member, Research Centre Member

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Cubero, F. J., Zhao, G., Nevzorova, Y. A., Hatting, M., Masaoudi, M. A., Verdier, J., Peng, J., Schaefer, F. M., Hermanns, N., Boekschoten, M. V., Grouls, C., Gassler, N., Kiessling, F., Muller, M., Davis, R. J., Liedtke, C., & Trautwein, C. (2015). Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Journal of Hepatology, 62(1), 140-149. https://doi.org/10.1016/j.jhep.2014.08.029

@article{bcd51051335a4a12be13bfadfe0dcda8,

title = "Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury",

abstract = "Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury.",

keywords = "Jnk1, Jnk2, Necrosis, Apoptosis, IKKγ/NEMO, HCC",

author = "Cubero, {Francisco J.} and Gang Zhao and Nevzorova, {Yulia A.} and Maximilian Hatting and Masaoudi, {Malika Al} and Julien Verdier and Jin Peng and Schaefer, {Frederik M.} and Nadine Hermanns and Boekschoten, {Mark V.} and Christoph Grouls and Nikolaus Gassler and Fabian Kiessling and Michael Muller and Davis, {Roger J.} and Christian Liedtke and Christian Trautwein",

year = "2015",

month = jan,

doi = "10.1016/j.jhep.2014.08.029",

language = "English",

volume = "62",

pages = "140--149",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "1",

}

Cubero, FJ, Zhao, G, Nevzorova, YA, Hatting, M, Masaoudi, MA, Verdier, J, Peng, J, Schaefer, FM, Hermanns, N, Boekschoten, MV, Grouls, C, Gassler, N, Kiessling, F, Muller, M, Davis, RJ, Liedtke, C & Trautwein, C 2015, 'Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury', Journal of Hepatology, vol. 62, no. 1, pp. 140-149. https://doi.org/10.1016/j.jhep.2014.08.029

TY - JOUR

T1 - Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

AU - Cubero, Francisco J.

AU - Zhao, Gang

AU - Nevzorova, Yulia A.

AU - Hatting, Maximilian

AU - Masaoudi, Malika Al

AU - Verdier, Julien

AU - Peng, Jin

AU - Schaefer, Frederik M.

AU - Hermanns, Nadine

AU - Boekschoten, Mark V.

AU - Grouls, Christoph

AU - Gassler, Nikolaus

AU - Kiessling, Fabian

AU - Muller, Michael

AU - Davis, Roger J.

AU - Liedtke, Christian

AU - Trautwein, Christian

PY - 2015/1

Y1 - 2015/1

N2 - Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury.

AB - Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signalling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury.

KW - Jnk1

KW - Jnk2

KW - Necrosis

KW - Apoptosis

KW - IKKγ/NEMO

KW - HCC

U2 - 10.1016/j.jhep.2014.08.029

DO - 10.1016/j.jhep.2014.08.029

M3 - Article

VL - 62

SP - 140

EP - 149

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 1

ER -

Hematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

Abstract

Keywords

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Michael Muller

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