Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study

Kristian M Bailey, Simon P R Romaine, Beryl M Jackson, Amanda J Farrin, Maria Efthymiou, Julian H Barth, Joanne Copeland, Terry McCormack, Andrew Whitehead, Marcus D Flather, Nilesh J Samani, Jane Nixon, Alistair S Hall, Anthony J Balmforth, SPACE ROCKET Trial Group

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83 Citations (Scopus)

Abstract

Pharmacogenetics aims to maximize benefits and minimize risks of drug treatment. Our objectives were to examine the influence of common variants of hepatic metabolism and transporter genes on the lipid-lowering response to statin therapy.
Original languageEnglish
Pages (from-to)276-85
Number of pages10
JournalCirculation: Cardiovascular Genetics
Volume3
Issue number3
DOIs
Publication statusPublished - Jun 2010

Keywords

  • ATP-Binding Cassette Transporters
  • Aged
  • Cholesterol, LDL
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System
  • Female
  • Fluorobenzenes
  • Genotype
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Neoplasm Proteins
  • Odds Ratio
  • Organic Anion Transporters
  • Polymorphism, Single Nucleotide
  • Pyrimidines
  • Regression Analysis
  • Simvastatin
  • Sulfonamides

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