Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study

Kristian M Bailey; Simon P R Romaine; Beryl M Jackson; Amanda J Farrin; Maria Efthymiou; Julian H Barth; Joanne Copeland; Terry McCormack; Andrew Whitehead; Marcus D Flather; Nilesh J Samani; Jane Nixon; Alistair S Hall; Anthony J Balmforth; SPACE ROCKET Trial Group

doi:10.1161/CIRCGENETICS.109.898502

Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study

Kristian M Bailey, Simon P R Romaine, Beryl M Jackson, Amanda J Farrin, Maria Efthymiou, Julian H Barth, Joanne Copeland, Terry McCormack, Andrew Whitehead, Marcus D Flather, Nilesh J Samani, Jane Nixon, Alistair S Hall, Anthony J Balmforth, SPACE ROCKET Trial Group

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

Pharmacogenetics aims to maximize benefits and minimize risks of drug treatment. Our objectives were to examine the influence of common variants of hepatic metabolism and transporter genes on the lipid-lowering response to statin therapy.

Original language	English
Pages (from-to)	276-85
Number of pages	10
Journal	Circulation: Cardiovascular Genetics
Volume	3
Issue number	3
DOIs	https://doi.org/10.1161/CIRCGENETICS.109.898502
Publication status	Published - Jun 2010

Keywords

ATP-Binding Cassette Transporters
Aged
Cholesterol, LDL
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Female
Fluorobenzenes
Genotype
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Male
Middle Aged
Myocardial Infarction
Neoplasm Proteins
Odds Ratio
Organic Anion Transporters
Polymorphism, Single Nucleotide
Pyrimidines
Regression Analysis
Simvastatin
Sulfonamides

Access to Document

10.1161/CIRCGENETICS.109.898502

Cite this

Bailey, K. M., Romaine, S. P. R., Jackson, B. M., Farrin, A. J., Efthymiou, M., Barth, J. H., Copeland, J., McCormack, T., Whitehead, A., Flather, M. D., Samani, N. J., Nixon, J., Hall, A. S., Balmforth, A. J., & SPACE ROCKET Trial Group (2010). Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study. Circulation: Cardiovascular Genetics, 3(3), 276-85. https://doi.org/10.1161/CIRCGENETICS.109.898502

Bailey, Kristian M ; Romaine, Simon P R ; Jackson, Beryl M ; Farrin, Amanda J ; Efthymiou, Maria ; Barth, Julian H ; Copeland, Joanne ; McCormack, Terry ; Whitehead, Andrew ; Flather, Marcus D ; Samani, Nilesh J ; Nixon, Jane ; Hall, Alistair S ; Balmforth, Anthony J ; SPACE ROCKET Trial Group. / Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction : the GEOSTAT-1 Study. In: Circulation: Cardiovascular Genetics. 2010 ; Vol. 3, No. 3. pp. 276-85.

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title = "Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study",

abstract = "Pharmacogenetics aims to maximize benefits and minimize risks of drug treatment. Our objectives were to examine the influence of common variants of hepatic metabolism and transporter genes on the lipid-lowering response to statin therapy.",

keywords = "ATP-Binding Cassette Transporters, Aged, Cholesterol, LDL, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Female, Fluorobenzenes, Genotype, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Myocardial Infarction, Neoplasm Proteins, Odds Ratio, Organic Anion Transporters, Polymorphism, Single Nucleotide, Pyrimidines, Regression Analysis, Simvastatin, Sulfonamides",

author = "Bailey, {Kristian M} and Romaine, {Simon P R} and Jackson, {Beryl M} and Farrin, {Amanda J} and Maria Efthymiou and Barth, {Julian H} and Joanne Copeland and Terry McCormack and Andrew Whitehead and Flather, {Marcus D} and Samani, {Nilesh J} and Jane Nixon and Hall, {Alistair S} and Balmforth, {Anthony J} and {SPACE ROCKET Trial Group}",

year = "2010",

month = jun,

doi = "10.1161/CIRCGENETICS.109.898502",

language = "English",

volume = "3",

pages = "276--85",

journal = "Circulation: Cardiovascular Genetics",

issn = "1942-325X",

publisher = "Lippincott, Williams and Wilkins",

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Bailey, KM, Romaine, SPR, Jackson, BM, Farrin, AJ, Efthymiou, M, Barth, JH, Copeland, J, McCormack, T, Whitehead, A, Flather, MD, Samani, NJ, Nixon, J, Hall, AS, Balmforth, AJ & SPACE ROCKET Trial Group 2010, 'Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study', Circulation: Cardiovascular Genetics, vol. 3, no. 3, pp. 276-85. https://doi.org/10.1161/CIRCGENETICS.109.898502

Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction : the GEOSTAT-1 Study. / Bailey, Kristian M; Romaine, Simon P R; Jackson, Beryl M; Farrin, Amanda J; Efthymiou, Maria; Barth, Julian H; Copeland, Joanne; McCormack, Terry; Whitehead, Andrew; Flather, Marcus D; Samani, Nilesh J; Nixon, Jane; Hall, Alistair S; Balmforth, Anthony J; SPACE ROCKET Trial Group.

In: Circulation: Cardiovascular Genetics, Vol. 3, No. 3, 06.2010, p. 276-85.

Research output: Contribution to journal › Article › peer-review

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T1 - Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction

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AU - Romaine, Simon P R

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AU - Farrin, Amanda J

AU - Efthymiou, Maria

AU - Barth, Julian H

AU - Copeland, Joanne

AU - McCormack, Terry

AU - Whitehead, Andrew

AU - Flather, Marcus D

AU - Samani, Nilesh J

AU - Nixon, Jane

AU - Hall, Alistair S

AU - Balmforth, Anthony J

AU - SPACE ROCKET Trial Group

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KW - Cytochrome P-450 CYP3A

KW - Cytochrome P-450 Enzyme System

KW - Female

KW - Fluorobenzenes

KW - Genotype

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Neoplasm Proteins

KW - Odds Ratio

KW - Organic Anion Transporters

KW - Polymorphism, Single Nucleotide

KW - Pyrimidines

KW - Regression Analysis

KW - Simvastatin

KW - Sulfonamides

U2 - 10.1161/CIRCGENETICS.109.898502

DO - 10.1161/CIRCGENETICS.109.898502

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