Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice

Daniela C Kroy; Fabienne Schumacher; Pierluigi Ramadori; Maximilian Hatting; Ina Bergheim; Nikolaus Gassler; Mark V Boekschoten; Michael Müller; Konrad L Streetz; Christian Trautwein

doi:10.1016/j.jhep.2014.05.019

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice

Daniela C Kroy, Fabienne Schumacher, Pierluigi Ramadori, Maximilian Hatting, Ina Bergheim, Nikolaus Gassler, Mark V Boekschoten, Michael Müller, Konrad L Streetz, Christian Trautwein

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Abstract

Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterized by progressive inflammation associated with oxidative stress and apoptosis finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor signaling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterize the role of c-met during NASH development.

Original language	English
Pages (from-to)	883–890
Number of pages	8
Journal	Journal of Hepatology
Volume	61
Issue number	4
Early online date	15 May 2014
DOIs	https://doi.org/10.1016/j.jhep.2014.05.019
Publication status	Published - Oct 2014

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10.1016/j.jhep.2014.05.019

Cite this

@article{049ac944e42a430091a18a1947434bea,

title = "Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice",

abstract = "Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterized by progressive inflammation associated with oxidative stress and apoptosis finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor signaling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterize the role of c-met during NASH development.",

author = "Kroy, {Daniela C} and Fabienne Schumacher and Pierluigi Ramadori and Maximilian Hatting and Ina Bergheim and Nikolaus Gassler and Boekschoten, {Mark V} and Michael M{\"u}ller and Streetz, {Konrad L} and Christian Trautwein",

note = "Copyright {\textcopyright} 2014. Published by Elsevier B.V.",

year = "2014",

month = oct,

doi = "10.1016/j.jhep.2014.05.019",

language = "English",

volume = "61",

pages = "883–890",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

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TY - JOUR

T1 - Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice

AU - Kroy, Daniela C

AU - Schumacher, Fabienne

AU - Ramadori, Pierluigi

AU - Hatting, Maximilian

AU - Bergheim, Ina

AU - Gassler, Nikolaus

AU - Boekschoten, Mark V

AU - Müller, Michael

AU - Streetz, Konrad L

AU - Trautwein, Christian

PY - 2014/10

Y1 - 2014/10

N2 - Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterized by progressive inflammation associated with oxidative stress and apoptosis finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor signaling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterize the role of c-met during NASH development.

AB - Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterized by progressive inflammation associated with oxidative stress and apoptosis finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor signaling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterize the role of c-met during NASH development.

U2 - 10.1016/j.jhep.2014.05.019

DO - 10.1016/j.jhep.2014.05.019

M3 - Article

C2 - 24845607

VL - 61

SP - 883

EP - 890

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 4

ER -