Heterobimetallic Catalysis: Platinum‐Gold‐Catalyzed Tandem Cyclization/C−X Coupling Reaction of (Hetero)Arylallenes with Nucleophiles

José Miguel Alonso, Maria Paz Muñoz

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18 Citations (Scopus)
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Abstract

Heterobimetallic catalysis offers new opportunities for reactivity and selectivity but still presents challenges, and only a few metal combinations have been explored so far. Reported here is a Pt‐Au heterobimetallic catalyst system for the synthesis of a family of multi‐heteroaromatic structures through tandem cyclization/C−X coupling reaction. Au‐catalyzed 6‐endo‐cyclization takes place as the first fast step. Pt‐Au clusters are proposed to be responsible for the increased reactivity in the second step, that is, the intermolecular nucleophilic addition which occurs through an outer‐sphere mechanism by hybrid homogeneous‐heterogeneous catalysis.
Original languageEnglish
Pages (from-to)4742-4746
Number of pages5
JournalAngewandte Chemie International Edition
Volume57
Issue number17
Early online date1 Mar 2018
DOIs
Publication statusPublished - 16 Apr 2018

Keywords

  • heterobimetallic catalysis
  • hybrid-homogeneous heterogeneous catalysis
  • platinum
  • gold
  • allenes

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