High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

A A Alsultan; B A Evans; E A Elsayed; S I Al-Thawadi; A Y Al-Taher; S G B Amyes; A M Al-Dughaym; A Hamouda

doi:10.1099/jmm.0.057216-0

High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

A A Alsultan, B A Evans, E A Elsayed, S I Al-Thawadi, A Y Al-Taher, S G B Amyes, A M Al-Dughaym, A Hamouda

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.

Original language	English
Pages (from-to)	885-888
Number of pages	4
Journal	Journal of Medical Microbiology
Volume	62
Early online date	1 Jun 2013
DOIs	https://doi.org/10.1099/jmm.0.057216-0
Publication status	Published - Jun 2013

Keywords

Acinetobacter Infections
Acinetobacter baumannii
Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
Diabetes Complications
Diabetes Mellitus
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Prevalence
Saudi Arabia
beta-Lactamases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1099/jmm.0.057216-0

Cite this

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title = "High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia",

abstract = "Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.",

keywords = "Acinetobacter Infections, Acinetobacter baumannii, Anti-Bacterial Agents, Bacterial Proteins, Carbapenems, Diabetes Complications, Diabetes Mellitus, Drug Resistance, Bacterial, Humans, Microbial Sensitivity Tests, Prevalence, Saudi Arabia, beta-Lactamases",

author = "Alsultan, {A A} and Evans, {B A} and Elsayed, {E A} and Al-Thawadi, {S I} and Al-Taher, {A Y} and Amyes, {S G B} and Al-Dughaym, {A M} and A Hamouda",

year = "2013",

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doi = "10.1099/jmm.0.057216-0",

language = "English",

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T1 - High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

AU - Alsultan, A A

AU - Evans, B A

AU - Elsayed, E A

AU - Al-Thawadi, S I

AU - Al-Taher, A Y

AU - Amyes, S G B

AU - Al-Dughaym, A M

AU - Hamouda, A

PY - 2013/6

Y1 - 2013/6

N2 - Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.

AB - Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.

KW - Acinetobacter Infections

KW - Acinetobacter baumannii

KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Carbapenems

KW - Diabetes Complications

KW - Diabetes Mellitus

KW - Drug Resistance, Bacterial

KW - Humans

KW - Microbial Sensitivity Tests

KW - Prevalence

KW - Saudi Arabia

KW - beta-Lactamases

U2 - 10.1099/jmm.0.057216-0

DO - 10.1099/jmm.0.057216-0

M3 - Article

C2 - 23518655

VL - 62

SP - 885

EP - 888

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

SN - 0022-2615

ER -