High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

P A Forsyth, T D Laing, A W Gibson, N B Rewcastle, P Brasher, G Sutherland, R N Johnston, D R Edwards

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.
Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalJournal of Neuro-Oncology
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1998

Keywords

  • Adult
  • Brain Neoplasms
  • Collagenases
  • Enzyme Activation
  • Fatal Outcome
  • Gelatinases
  • Glioblastoma
  • Head and Neck Neoplasms
  • Humans
  • Lymphatic Metastasis
  • Male
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
  • Metalloendopeptidases
  • Orbital Neoplasms
  • Skull Neoplasms
  • Tracheal Neoplasms

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