High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

P A Forsyth; T D Laing; A W Gibson; N B Rewcastle; P Brasher; G Sutherland; R N Johnston; D R Edwards

doi:10.1023/A:1005879027267

High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

P A Forsyth, T D Laing, A W Gibson, N B Rewcastle, P Brasher, G Sutherland, R N Johnston, D R Edwards

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.

Original language	English
Pages (from-to)	21-29
Number of pages	9
Journal	Journal of Neuro-Oncology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1023/A:1005879027267
Publication status	Published - Jan 1998

Keywords

Adult
Brain Neoplasms
Collagenases
Enzyme Activation
Fatal Outcome
Gelatinases
Glioblastoma
Head and Neck Neoplasms
Humans
Lymphatic Metastasis
Male
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Metalloendopeptidases
Orbital Neoplasms
Skull Neoplasms
Tracheal Neoplasms

Access to Document

10.1023/A:1005879027267

Cite this

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title = "High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma",

abstract = "Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.",

keywords = "Adult, Brain Neoplasms, Collagenases, Enzyme Activation, Fatal Outcome, Gelatinases, Glioblastoma, Head and Neck Neoplasms, Humans, Lymphatic Metastasis, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Metalloendopeptidases, Orbital Neoplasms, Skull Neoplasms, Tracheal Neoplasms",

author = "Forsyth, {P A} and Laing, {T D} and Gibson, {A W} and Rewcastle, {N B} and P Brasher and G Sutherland and Johnston, {R N} and Edwards, {D R}",

year = "1998",

month = jan,

doi = "10.1023/A:1005879027267",

language = "English",

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T1 - High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

AU - Forsyth, P A

AU - Laing, T D

AU - Gibson, A W

AU - Rewcastle, N B

AU - Brasher, P

AU - Sutherland, G

AU - Johnston, R N

AU - Edwards, D R

PY - 1998/1

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N2 - Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.

AB - Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.

KW - Adult

KW - Brain Neoplasms

KW - Collagenases

KW - Enzyme Activation

KW - Fatal Outcome

KW - Gelatinases

KW - Glioblastoma

KW - Head and Neck Neoplasms

KW - Humans

KW - Lymphatic Metastasis

KW - Male

KW - Matrix Metalloproteinase 2

KW - Matrix Metalloproteinase 9

KW - Metalloendopeptidases

KW - Orbital Neoplasms

KW - Skull Neoplasms

KW - Tracheal Neoplasms

U2 - 10.1023/A:1005879027267

DO - 10.1023/A:1005879027267

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JO - Journal of Neuro-Oncology

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