High-quality metagenome assembly from long accurate reads with metaMDBG

Gaëtan Benoit, Sébastien Raguideau, Robert James, Adam M. Phillippy, Rayan Chikhi, Christopher Quince

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
1 Downloads (Pure)

Abstract

We introduce metaMDBG, a metagenomics assembler for PacBio HiFi reads. MetaMDBG combines a de Bruijn graph assembly in a minimizer space with an iterative assembly over sequences of minimizers to address variations in genome coverage depth and an abundance-based filtering strategy to simplify strain complexity. For complex communities, we obtained up to twice as many high-quality circularized prokaryotic metagenome-assembled genomes as existing methods and had better recovery of viruses and plasmids.

Original languageEnglish
Pages (from-to)1378-1383
Number of pages6
JournalNature Biotechnology
Volume42
Issue number9
Early online date2 Jan 2024
DOIs
Publication statusPublished - Sept 2024

Cite this