Highly enantioselective total synthesis of (−)-(3′S)-lomatin and (+)-(3′S,4′R)-trans-khellactone

Philip C. Bulman Page, Louise F. Appleby, David Day, Yohan Chan, Benjamin R. Buckley, Steven M. Allin, Michael J. McKenzie

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Concise highly enantioselective three-step syntheses are described for (-)-(3'S)-lomatin and (+)-(3'S,4'R)-trans-khellactone from 7-hydroxycoumarin in 97% ee and in 57% and 58% overall yields, respectively, using nonaqueous enantioselective epoxidation by an iminium salt as the key step.
Original languageEnglish
Pages (from-to)1991-1993
Number of pages3
JournalOrganic Letters
Issue number9
Publication statusPublished - 8 Apr 2009

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