Hormonal calcium regulation and calcium setpoint in offspring of bitches with different calcium intakes during pregnancy

I. Schoenmakers, J. A. Mol, H. A. W. Hazewinkel

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


High maternal calcium (Ca) intake may lead to alterations in development and differentiation of fetal tissues and may result in altered 'programming' of Ca homeostasis, with eventual effects on Ca handling and skeletal development in the offspring during later life. In bitches fed a diet with a Ca intake three times above recommendations (3.27g/100g vs 1.14g/100g dry matter) during the second half of pregnancy, the plasma concentration of 1,25 dihydroxy cholecalciferol (1,25 (OH)2 vit D) appeared to decrease, while plasma Ca, phosphorus (P), parathyroid hormone (PTH) and calcitonin (CT) concentrations remained unchanged. High maternal Ca intake did not result in altered basal or stimulated plasma concentrations of Ca, P, PTH, CT and 1,25 (OH)2 vit D in the offspring (n = 7) when compared with pups from bitches fed a normal Ca diet during the entire pregnancy (controls, n = 7). The Ca setpoint for PTH secretion (CaSforPTH) was therefore not different from controls. From this pilot study it may be concluded that excessive Ca intake during late pregnancy in the bitch has no deleterious effects on hormonal Ca homeostasis in the offspring.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalJournal of Animal Physiology and Animal Nutrition
Issue number1
Publication statusPublished - Feb 2000

Cite this