Host susceptibility and clinical outcomes in toll-like receptor 5–deficient patients with typhoid fever in Vietnam

Sarah J. Dunstan; Thomas R. Hawn; Nguyen Thi Hue; Christopher P. Parry; Vo An Ho; Ha Vinh; To Song Diep; Deborah House; John Wain; Alan Aderem; Tran Tinh Hien; Jeremy J. Farrar

doi:10.1086/428593

Host susceptibility and clinical outcomes in toll-like receptor 5–deficient patients with typhoid fever in Vietnam

Sarah J. Dunstan, Thomas R. Hawn, Nguyen Thi Hue, Christopher P. Parry, Vo An Ho, Ha Vinh, To Song Diep, Deborah House, John Wain, Alan Aderem, Tran Tinh Hien, Jeremy J. Farrar

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5392STOP) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5392STOP was associated with typhoid fever. The frequency of TLR5392STOP was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. Furthermore, TLR5 deficiency had no measurable effect on a number of clinical parameters associated with typhoid fever, including fever clearance time, pathogen burden, disease severity, or age at acquisition of disease. TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands

Original language	English
Pages (from-to)	1068-1071
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	191
Issue number	7
DOIs	https://doi.org/10.1086/428593
Publication status	Published - 1 Apr 2005

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Cite this

@article{6184282e85d645e89d178bded1664e0a,

title = "Host susceptibility and clinical outcomes in toll-like receptor 5–deficient patients with typhoid fever in Vietnam",

abstract = "Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5392STOP) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5392STOP was associated with typhoid fever. The frequency of TLR5392STOP was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. Furthermore, TLR5 deficiency had no measurable effect on a number of clinical parameters associated with typhoid fever, including fever clearance time, pathogen burden, disease severity, or age at acquisition of disease. TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands",

author = "Dunstan, {Sarah J.} and Hawn, {Thomas R.} and Hue, {Nguyen Thi} and Parry, {Christopher P.} and Ho, {Vo An} and Ha Vinh and Diep, {To Song} and Deborah House and John Wain and Alan Aderem and Hien, {Tran Tinh} and Farrar, {Jeremy J.}",

year = "2005",

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doi = "10.1086/428593",

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T1 - Host susceptibility and clinical outcomes in toll-like receptor 5–deficient patients with typhoid fever in Vietnam

AU - Dunstan, Sarah J.

AU - Hawn, Thomas R.

AU - Hue, Nguyen Thi

AU - Parry, Christopher P.

AU - Ho, Vo An

AU - Vinh, Ha

AU - Diep, To Song

AU - House, Deborah

AU - Wain, John

AU - Aderem, Alan

AU - Hien, Tran Tinh

AU - Farrar, Jeremy J.

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5392STOP) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5392STOP was associated with typhoid fever. The frequency of TLR5392STOP was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. Furthermore, TLR5 deficiency had no measurable effect on a number of clinical parameters associated with typhoid fever, including fever clearance time, pathogen burden, disease severity, or age at acquisition of disease. TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands

AB - Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5392STOP) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5392STOP was associated with typhoid fever. The frequency of TLR5392STOP was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. Furthermore, TLR5 deficiency had no measurable effect on a number of clinical parameters associated with typhoid fever, including fever clearance time, pathogen burden, disease severity, or age at acquisition of disease. TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands

U2 - 10.1086/428593

DO - 10.1086/428593

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