Host Susceptibility and Clinical Outcomes in Toll‐like Receptor 5–Deficient Patients with Typhoid Fever in Vietnam

Sarah J. Dunstan, Thomas R. Hawn, Nguyen Thi Hue, Christopher P. Parry, Vo An Ho, Ha Vinh, To Song Diep, Deborah House, John Wain, Alan Aderem, Tran Tinh Hien, Jeremy J. Farrar

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Abstract

Toll-like receptor 5 (TLR5) mediates innate immune responses to bacterial pathogens by binding to flagellin. A polymorphism in the TLR5 gene introduces a premature stop codon (TLR5392STOP) that is associated with susceptibility to legionnaires disease. Here we investigated whether TLR5392STOP was associated with typhoid fever. The frequency of TLR5392STOP was not significantly different in 565 patients with typhoid fever and 281 ethnically matched control subjects. Furthermore, TLR5 deficiency had no measurable effect on a number of clinical parameters associated with typhoid fever, including fever clearance time, pathogen burden, disease severity, or age at acquisition of disease. TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands
Original languageEnglish
Pages (from-to)1068-1071
Number of pages4
JournalJournal of Infectious Diseases
Volume191
Issue number7
DOIs
Publication statusPublished - 1 Apr 2005

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