How sweet are our gut beneficial bacteria? A focus on protein glycosylation in Lactobacillus

Dimitrios Latousakis, Nathalie Juge

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Protein glycosylation is emerging as an important feature in bacteria. Protein glycosylation systems have been reported and studied in many pathogenic bacteria, revealing an important diversity of glycan structures and pathways within and between bacterial species. These systems play key roles in virulence and pathogenicity. More recently, a large number of bacterial proteins have been found to be glycosylated in gut commensal bacteria. We present an overview of bacterial protein glycosylation systems (O- and N-glycosylation) in bacteria, with a focus on glycoproteins from gut commensal bacteria, particularly Lactobacilli. These emerging studies underscore the importance of bacterial protein glycosylation in the interaction of the gut microbiota with the host.
Original languageEnglish
Article number136
JournalInternational Journal of Molecular Sciences
Issue number1
Publication statusPublished - 3 Jan 2018


  • protein glycosylation
  • gut commensal bacteria
  • Lactobacillus
  • glycoproteins
  • adhesins
  • lectins
  • O-glycosylation
  • N-glycosylation
  • probiotics

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