TY - JOUR
T1 - Human diseases reveal novel roles for neural laminins
AU - Colognato, Holly
AU - ffrench-Constant, Charles
AU - Feltri, Maria Laura
N1 - Funding Information: Work in the laboratories is funded by a Career Transition Fellowship from the National Multiple Sclerosis Society (H.C.), the Wellcome Trust and the FP5 programme of the EU (C.ff-C.), and the NIH (R01-NS045630) and Telethon, Italy (M.L.F.).
PY - 2005/9
Y1 - 2005/9
N2 - Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.
AB - Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.
UR - http://www.scopus.com/inward/record.url?scp=23944514976&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2005.07.004
DO - 10.1016/j.tins.2005.07.004
M3 - Review article
C2 - 16043237
AN - SCOPUS:23944514976
SN - 0166-2236
VL - 28
SP - 480
EP - 486
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 9
ER -