Human diseases reveal novel roles for neural laminins

Holly Colognato, Charles Ffrench-Constant, Maria Laura Feltri

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.

Original languageEnglish
Pages (from-to)480-486
Number of pages7
JournalTrends in Neurosciences
Volume28
Issue number9
DOIs
Publication statusPublished - 1 Sep 2005

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