Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole

A J G Bell, R J Nicholls, A Forbes, H J Ellis, P J Ciclitira

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20 Citations (Scopus)

Abstract

The gut flora may play an important role in the pathogenesis of inflammatory bowel disease. An ileal reservoir or pouch can be created to replace the excised rectum after proctocolectomy. In patients with ulcerative colitis this is subject to inflammation and termed pouchitis. Using bacteria from patients the authors sought evidence for the presence rather than the identity of a pathogenic species in pouchitis, and for its absence in healthy pouches by the differential effect on lymphocyte proliferation.
Original languageEnglish
Pages (from-to)1801-1805
Number of pages5
JournalGut
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents
  • Bacteria
  • Cell Division
  • Cells, Cultured
  • Colonic Pouches
  • Female
  • Humans
  • Lymphocyte Activation
  • Male
  • Metronidazole
  • Middle Aged
  • Pouchitis
  • Sonication

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