TY - JOUR
T1 - Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP
AU - Harrison, Jennifer A.
AU - Kartha, K. P. Ravindranathan
AU - Turnbull, W. Bruce
AU - Scheuerl, Shona L.
AU - Naismith, James H.
AU - Schenkman, Sergio
AU - Field, Robert A.
N1 - Funding Information: This work was supported by the BBSRC, the Wellcome Trust (Grant refs: 042472 and 040331), GlaxoWellcome, and the Association for International Cancer Research.
PY - 2001/1/22
Y1 - 2001/1/22
N2 - NeuAc-α-2,3-Gal-β-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-α-2,3-Gal-β-O-PNP were apparent.
AB - NeuAc-α-2,3-Gal-β-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-α-2,3-Gal-β-O-PNP were apparent.
UR - https://www.scopus.com/pages/publications/0035931354
U2 - 10.1016/S0960-894X(00)00611-9
DO - 10.1016/S0960-894X(00)00611-9
M3 - Article
C2 - 11206445
AN - SCOPUS:0035931354
SN - 0960-894X
VL - 11
SP - 141
EP - 144
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -