Hydroxy- and Alkoxycyclizations of Enynes Catalyzed by Platinum(II) Chloride

Antonio M. Echavarren, Maria Munoz-Herranz, María Méndez, Cristina Nevado, Diego J. Cárdenas

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The cyclization of 1-en-6-ynes catalyzed by PtCl2 in the presence of water or alcohols affords five or six-membered ring carbocycles containing hydroxy or alkoxy functional groups in high yields. The alkoxycyclizations can also be performed with AuCl3 as catalyst. The reaction is stereospecific, atom-economical, and takes place in environmentally friendly solvents.
Original languageEnglish
Pages (from-to)2898-2902
Number of pages5
JournalSynthesis
Issue number18
DOIs
Publication statusPublished - 2003

Cite this