Hypermanganesemia in long-term intravenous nutrition and chronic liver disease

Catherine A. Wardle, Alastair Forbes, Norman B. Roberts, A. V. Jawhari, Alan Shenkin

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39 Citations (Scopus)


Hypermanganesemia and cholestatic liver disease are both recognized complications of long-term IV nutrition. Manganese is primarily excreted in bile, and recent studies have indicated that manganese toxicity may play a role in the pathogenesis of IV nutrition-associated cholestasis.
Original languageEnglish
Pages (from-to)350-355
Number of pages6
JournalJournal of Parenteral and Enteral Nutrition
Issue number6
Publication statusPublished - 1999


  • Adult
  • Aged
  • Alkaline Phosphatase
  • Chronic Disease
  • Female
  • Humans
  • Liver Diseases
  • Magnetic Resonance Imaging
  • Male
  • Manganese
  • Middle Aged
  • Parenteral Nutrition, Home
  • gamma-Glutamyltransferase

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