Hypothalamic food intake regulation in a cancer-cachectic mouse model

Jvalini T Dwarkasing, Miriam van Dijk, Francina J Dijk, Mark V Boekschoten, Joyce Faber, Josep M Argilès, Alessandro Laviano, Michael Müller, Renger F Witkamp, Klaske van Norren

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17 Citations (Scopus)

Abstract

Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.
Original languageEnglish
Pages (from-to)159-169
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2014

Keywords

  • Cancer
  • Hypothalamus
  • Appetite
  • Serotonin
  • Transcriptomics
  • Anorexia

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