Hypothalamic food intake regulation in a cancer-cachectic mouse model

Jvalini T Dwarkasing; Miriam van Dijk; Francina J Dijk; Mark V Boekschoten; Joyce Faber; Josep M Argilès; Alessandro Laviano; Michael Müller; Renger F Witkamp; Klaske van Norren

doi:10.1007/s13539-013-0121-y

Hypothalamic food intake regulation in a cancer-cachectic mouse model

Jvalini T Dwarkasing, Miriam van Dijk, Francina J Dijk, Mark V Boekschoten, Joyce Faber, Josep M Argilès, Alessandro Laviano, Michael Müller, Renger F Witkamp, Klaske van Norren

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.

Original language	English
Pages (from-to)	159-169
Journal	Journal of Cachexia, Sarcopenia and Muscle
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s13539-013-0121-y
Publication status	Published - Jun 2014

Keywords

Cancer
Hypothalamus
Appetite
Serotonin
Transcriptomics
Anorexia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s13539-013-0121-y

Cite this

@article{d06909ef2b4b4109bf56ae0088282ca3,

title = "Hypothalamic food intake regulation in a cancer-cachectic mouse model",

abstract = "Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.",

keywords = "Cancer, Hypothalamus, Appetite, Serotonin, Transcriptomics, Anorexia",

author = "Dwarkasing, {Jvalini T} and {van Dijk}, Miriam and Dijk, {Francina J} and Boekschoten, {Mark V} and Joyce Faber and Argil{\`e}s, {Josep M} and Alessandro Laviano and Michael M{\"u}ller and Witkamp, {Renger F} and {van Norren}, Klaske",

year = "2014",

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language = "English",

volume = "5",

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journal = "Journal of Cachexia, Sarcopenia and Muscle",

issn = "2190-5991",

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Hypothalamic food intake regulation in a cancer-cachectic mouse model. / Dwarkasing, Jvalini T; van Dijk, Miriam; Dijk, Francina J; Boekschoten, Mark V; Faber, Joyce; Argilès, Josep M; Laviano, Alessandro; Müller, Michael; Witkamp, Renger F; van Norren, Klaske.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 5, No. 2, 06.2014, p. 159-169.

Research output: Contribution to journal › Article › peer-review

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AU - Dwarkasing, Jvalini T

AU - van Dijk, Miriam

AU - Dijk, Francina J

AU - Boekschoten, Mark V

AU - Faber, Joyce

AU - Argilès, Josep M

AU - Laviano, Alessandro

AU - Müller, Michael

AU - Witkamp, Renger F

AU - van Norren, Klaske

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AB - Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.

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