Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A Eeles; Ali Amin Al Olama; Sara Benlloch; Edward J Saunders; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Maya Ghoussaini; Craig Luccarini; Joe Dennis; Sarah Jugurnauth-Little; Tokhir Dadaev; David E Neal; Freddie C Hamdy; Jenny L Donovan; Ken Muir; Graham G Giles; Gianluca Severi; Fredrik Wiklund; Henrik Gronberg; Christopher A Haiman; Fredrick Schumacher; Brian E Henderson; Loic Le Marchand; Sara Lindstrom; Peter Kraft; David J Hunter; Susan Gapstur; Stephen J Chanock; Sonja I Berndt; Demetrius Albanes; Gerald Andriole; Johanna Schleutker; Maren Weischer; Federico Canzian; Elio Riboli; Tim J Key; Ruth C Travis; Daniele Campa; Sue A Ingles; Esther M John; Richard B Hayes; Paul D P Pharoah; Nora Pashayan; Kay-Tee Khaw; Janet L Stanford; Elaine A Ostrander; Lisa B Signorello; Stephen N Thibodeau; Dan Schaid; Colin S Cooper; COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

doi:10.1038/ng.2560

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E Neal, Freddie C Hamdy, Jenny L Donovan, Ken Muir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A HaimanFredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen J Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue A Ingles, Esther M John, Richard B Hayes, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Dan Schaid, Colin S Cooper, COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

Research output: Contribution to journal › Article › peer-review

463 Citations (Scopus)

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P

Original language	English
Pages (from-to)	385-91, 391e1-2
Journal	Nature Genetics
Volume	45
Issue number	4
DOIs	https://doi.org/10.1038/ng.2560
Publication status	Published - Apr 2013

Keywords

Case-Control Studies
Cooperative Behavior
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Male
Meta-Analysis as Topic
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.2560

Cite this

Eeles, R. A., Olama, A. A. A., Benlloch, S., Saunders, E. J., Leongamornlert, D. A., Tymrakiewicz, M., Ghoussaini, M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., Dadaev, T., Neal, D. E., Hamdy, F. C., Donovan, J. L., Muir, K., Giles, G. G., Severi, G., Wiklund, F., Gronberg, H., ... COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative (2013). Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 45(4), 385-91, 391e1-2. https://doi.org/10.1038/ng.2560

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abstract = "Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P ",

keywords = "Case-Control Studies, Cooperative Behavior, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors",

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Eeles, RA, Olama, AAA, Benlloch, S, Saunders, EJ, Leongamornlert, DA, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth-Little, S, Dadaev, T, Neal, DE, Hamdy, FC, Donovan, JL, Muir, K, Giles, GG, Severi, G, Wiklund, F, Gronberg, H, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Lindstrom, S, Kraft, P, Hunter, DJ, Gapstur, S, Chanock, SJ, Berndt, SI, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Canzian, F, Riboli, E, Key, TJ, Travis, RC, Campa, D, Ingles, SA, John, EM, Hayes, RB, Pharoah, PDP, Pashayan, N, Khaw, K-T, Stanford, JL, Ostrander, EA, Signorello, LB, Thibodeau, SN, Schaid, D, Cooper, CS & COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative 2013, 'Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array', Nature Genetics, vol. 45, no. 4, pp. 385-91, 391e1-2. https://doi.org/10.1038/ng.2560

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AU - Olama, Ali Amin Al

AU - Benlloch, Sara

AU - Saunders, Edward J

AU - Leongamornlert, Daniel A

AU - Tymrakiewicz, Malgorzata

AU - Ghoussaini, Maya

AU - Luccarini, Craig

AU - Dennis, Joe

AU - Jugurnauth-Little, Sarah

AU - Dadaev, Tokhir

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Muir, Ken

AU - Giles, Graham G

AU - Severi, Gianluca

AU - Wiklund, Fredrik

AU - Gronberg, Henrik

AU - Haiman, Christopher A

AU - Schumacher, Fredrick

AU - Henderson, Brian E

AU - Le Marchand, Loic

AU - Lindstrom, Sara

AU - Kraft, Peter

AU - Hunter, David J

AU - Gapstur, Susan

AU - Chanock, Stephen J

AU - Berndt, Sonja I

AU - Albanes, Demetrius

AU - Andriole, Gerald

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Canzian, Federico

AU - Riboli, Elio

AU - Key, Tim J

AU - Travis, Ruth C

AU - Campa, Daniele

AU - Ingles, Sue A

AU - John, Esther M

AU - Hayes, Richard B

AU - Pharoah, Paul D P

AU - Pashayan, Nora

AU - Khaw, Kay-Tee

AU - Stanford, Janet L

AU - Ostrander, Elaine A

AU - Signorello, Lisa B

AU - Thibodeau, Stephen N

AU - Schaid, Dan

AU - Cooper, Colin S

AU - COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative

PY - 2013/4

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AB - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P

KW - Case-Control Studies

KW - Cooperative Behavior

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Meta-Analysis as Topic

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

KW - Risk Factors

U2 - 10.1038/ng.2560

DO - 10.1038/ng.2560

M3 - Article

C2 - 23535732

VL - 45

SP - 385-91, 391e1-2

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -