Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy

Ralf Kiesslich, Martin Goetz, Elizabeth M Angus, Qiuping Hu, Yanfang Guan, Chris Potten, Terry Allen, Markus F Neurath, Noah F Shroyer, Marshall H Montrose, Alastair J M Watson

Research output: Contribution to journalArticlepeer-review

190 Citations (Scopus)


Confocal endomicroscopy is an emerging technology that poses the endoscopist with challenges for identifying epithelial structures in the human intestine. We have shown previously that the murine intestinal epithelium is punctuated by gaps caused by cell shedding. The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding.
Original languageEnglish
Pages (from-to)1769-1778
Number of pages10
Issue number6
Publication statusPublished - Dec 2007


  • Adolescent
  • Adult
  • Aged
  • Animals
  • Colonoscopy
  • Epithelial Cells
  • Female
  • Humans
  • Intestine, Large
  • Intestine, Small
  • Male
  • Mice
  • Microscopy, Confocal
  • Middle Aged
  • Tumor Necrosis Factor-alpha

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